Table 1 Demographic data and NID2 methylation levels of the samples
From: Evaluation of NID2 promoter methylation for screening of Oral squamous cell carcinoma
Healthy control (n = 50) | Potentially malignant group (n = 70) | Cancer group (n = 43) | P-value | ||
|---|---|---|---|---|---|
Age mean (SD) | 55.6 (15.3) | 58.2 (13.9) | 53.8 (15.6) | 57.3 (17.5) | 0.537 |
Gender | Male, 54 (54%) | Male, 26 (72.5%) | Male, 13 (36.7%) | Male, 23 (53.5%) | 0.345 |
Female, 46 (46%) | Female, 14 (27.5%) | Female, 17 (63.3%) | Female, 20 (46.5%) | ||
Sample collection | |||||
Oral rinse | Healthy controls, 50a | Smokers, 40 | Oral squamous cell carcinoma, 43 | ||
Oral swab | Healthy controls, 50a | Oral lichen planus, 30 | Oral squamous cell carcinoma, 22 | ||
Histological grade | Well-differentiated, 24 | ||||
Moderately differentiated, 13 | |||||
Poorly differentiated, 5 | |||||
Clinical stage | Stage I, 7 | ||||
Stage II, 10 | |||||
Stage III, 4 | |||||
Stage IV, 22 | |||||
Methylated NID2 concentration | |||||
(ng/ul) [mean(SD)] | |||||
Oral rinse | 0 (0) | 0 (0) | 4.33 (7.69) | < 0.001 | |
Oral swab | 0 (0) | 0 (0) | 4.00 (8.34) | < 0.001 | |