Skip to main content

Table 1 Tumour subtypes across age of onset groups

From: Mutational landscape differences between young-onset and older-onset breast cancer patients

Tumour TypeYoungOlderOldestTotalp-value (young vs. older)p-value (young vs. oldest)
Basal-like17 (22%)129 (16.7%)45 (12%)146 (17.1%)0.270.03*
HER2+3 (4%)66 (8.5%)27 (7%)69 (8.1%)0.190.33
Luminal A39 (50%)393 (50.8%)219 (59%)432 (50.7%)0.910.17
Luminal B18 (23%)164 (21.2%)75 (20%)182 (21.4%)0.670.54
Normal-like1 (1%)22 (2.8%)6 (2%)23 (2.7%)0.711.00
  1. Frequency and proportion of tumours in each age of onset group of each PAM50 tumour subtype. Entries are the number of samples of each subtype (% of samples in age of onset group). The p-values were calculated using Fisher’s exact test (* indicates statistical significance at the 0.05 level). Age of onset groups were defined as “Young”: breast tumours diagnosed at ≤40 years of age (n = 78), “Older”: breast tumours diagnosed > 40 years of age (n = 774), and “Oldest”: breast tumours diagnosed > 60 years of age (n = 372). HER2+: human epidermal growth factor receptor 2 over-expressing; PAM50: prediction analysis of microarrays 50 gene set