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Table 3 Univariate and multivariate analysis for factors of complete response

From: Risk factors for aspiration pneumonia during concurrent chemoradiotherapy or bio-radiotherapy for head and neck cancer

Variables Univariate analysis Multivariate analysis
Odds ratio 95% CI P Odds ratio 95% CI P
Age < 70 vs. ≥70 1.23 0.76–2.01 0.40    
Gender Male vs. Female 0.80 1.41–1.53 0.49    
ECOG Performance status 0–1 vs.2–3 4.14 1.58–10.8 0.0037 2.30 0.81–6.52 0.12
BMI < 20 vs. ≥20 0.51 0.62–7.47 0.227    
Primary site Oropharynx vs. others 1.02 0.62–1.68 0.94    
T-classification 1–2 vs. 3–4 1.97 1.25–3.12 0.0035 1.56 0.95–2.57 0.082
N-classification 0-2b vs. 2c-3 2.31 1.43–3.73 < 0.001 1.57 0.90–2.73 0.11
Histology SCC vs. others 0.36 0.12–1.08 0.069    
Brinkman index < 500 vs. ≥500 1.16 0.73–1.84 0.54    
Habitual alcoholic consumption Yes vs. No 0.64 0.40–1.01 0.055    
Use of ACEi or ARB Yes vs. No 0.97 0.55–1.69 0.91    
Use of PPI or H2 blocker Yes vs. No 1.14 0.73–1.75 0.59    
Oral hygiene before treatment Good vs. Poor 1.58 1.01–2.48 0.043 1.11 0.68–1.83 0.68
Coexistence of other malignancies Yes vs. No 0.89 0.64–1.23 0.48    
Charlson comorbidity index 0–1 vs. ≥2 1.32 0.79–2.22 0.29    
Serum albumin before treatment Within normal limits vs. less than normal range 2.78 1.59–4.77 < 0.001 1.88 0.95–3.75 0.069
Hemoglobin before treatment Within normal limits vs. less than normal range 1.75 1.09–2.79 0.020 1.07 0.60–1.91 0.82
Use of sleeping pills before treatment Yes .vs No 0.63 0.41–0.98 0.042 0.75 0.39–1.43 0.38
Induction chemotherapy Yes vs. No 1.15 0.69–1.89 0.60    
Concurrent chemotherapy regimen CDDP vs. others 1.15 0.70–1.89 0.57    
Radiation technique Conventional 3D-CRT vs. IMRT 0.60 0.37–0.98 0.043 0.65 0.38–1.12 0.12
Radiation dose 70Gy vs. <70Gy 4.13 1.18–14.4 0.026 3.70 0.97–14.1 0.056
Irradiation field Local vs. whole neck 0.98 0.56–1.72 0.95    
Percutaneous endoscopic gastrostomy prior to treatment Yes vs. No 0.50 0.31–0.80 0.041 0.68 0.40–1.15 0.15
Treatment Inpatient vs. Outpatient 0.62 0.40–0.96 0.032 0.86 0.52–1.40 0.53
The worst mucositis grade during treatment 1–2 vs. 3–4 1.09 0.70–1.70 0.70    
The worst dysphagia score during treatment 1–2 vs. 3–4 1.39 0.89–2.17 0.15    
Aspiration pneumonia during treatment Yes vs. No 0.38 0.23–0.62 < 0.001 0.52 0.30–0.90 0.020