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Table 3 Univariate and multivariate analysis for factors of complete response

From: Risk factors for aspiration pneumonia during concurrent chemoradiotherapy or bio-radiotherapy for head and neck cancer

VariablesUnivariate analysisMultivariate analysis
Odds ratio95% CIPOdds ratio95% CIP
Age < 70 vs. ≥701.230.76–2.010.40   
Gender Male vs. Female0.801.41–1.530.49   
ECOG Performance status 0–1 vs.2–34.141.58–10.80.00372.300.81–6.520.12
BMI < 20 vs. ≥200.510.62–7.470.227   
Primary site Oropharynx vs. others1.020.62–1.680.94   
T-classification 1–2 vs. 3–41.971.25–3.120.00351.560.95–2.570.082
N-classification 0-2b vs. 2c-32.311.43–3.73< 0.0011.570.90–2.730.11
Histology SCC vs. others0.360.12–1.080.069   
Brinkman index < 500 vs. ≥5001.160.73–1.840.54   
Habitual alcoholic consumption Yes vs. No0.640.40–1.010.055   
Use of ACEi or ARB Yes vs. No0.970.55–1.690.91   
Use of PPI or H2 blocker Yes vs. No1.140.73–1.750.59   
Oral hygiene before treatment Good vs. Poor1.581.01–2.480.0431.110.68–1.830.68
Coexistence of other malignancies Yes vs. No0.890.64–1.230.48   
Charlson comorbidity index 0–1 vs. ≥21.320.79–2.220.29   
Serum albumin before treatment Within normal limits vs. less than normal range2.781.59–4.77< 0.0011.880.95–3.750.069
Hemoglobin before treatment Within normal limits vs. less than normal range1.751.09–2.790.0201.070.60–1.910.82
Use of sleeping pills before treatment Yes .vs No0.630.41–0.980.0420.750.39–1.430.38
Induction chemotherapy Yes vs. No1.150.69–1.890.60   
Concurrent chemotherapy regimen CDDP vs. others1.150.70–1.890.57   
Radiation technique Conventional 3D-CRT vs. IMRT0.600.37–0.980.0430.650.38–1.120.12
Radiation dose 70Gy vs. <70Gy4.131.18–14.40.0263.700.97–14.10.056
Irradiation field Local vs. whole neck0.980.56–1.720.95   
Percutaneous endoscopic gastrostomy prior to treatment Yes vs. No0.500.31–0.800.0410.680.40–1.150.15
Treatment Inpatient vs. Outpatient0.620.40–0.960.0320.860.52–1.400.53
The worst mucositis grade during treatment 1–2 vs. 3–41.090.70–1.700.70   
The worst dysphagia score during treatment 1–2 vs. 3–41.390.89–2.170.15   
Aspiration pneumonia during treatment Yes vs. No0.380.23–0.62< 0.0010.520.30–0.900.020
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