|
Age < 70 vs. ≥70
|
1.23
|
0.76–2.01
|
0.40
| | | |
|
Gender Male vs. Female
|
0.80
|
1.41–1.53
|
0.49
| | | |
|
ECOG Performance status 0–1 vs.2–3
|
4.14
|
1.58–10.8
|
0.0037
|
2.30
|
0.81–6.52
|
0.12
|
|
BMI < 20 vs. ≥20
|
0.51
|
0.62–7.47
|
0.227
| | | |
|
Primary site Oropharynx vs. others
|
1.02
|
0.62–1.68
|
0.94
| | | |
|
T-classification 1–2 vs. 3–4
|
1.97
|
1.25–3.12
|
0.0035
|
1.56
|
0.95–2.57
|
0.082
|
|
N-classification 0-2b vs. 2c-3
|
2.31
|
1.43–3.73
|
< 0.001
|
1.57
|
0.90–2.73
|
0.11
|
|
Histology SCC vs. others
|
0.36
|
0.12–1.08
|
0.069
| | | |
|
Brinkman index < 500 vs. ≥500
|
1.16
|
0.73–1.84
|
0.54
| | | |
|
Habitual alcoholic consumption Yes vs. No
|
0.64
|
0.40–1.01
|
0.055
| | | |
|
Use of ACEi or ARB Yes vs. No
|
0.97
|
0.55–1.69
|
0.91
| | | |
|
Use of PPI or H2 blocker Yes vs. No
|
1.14
|
0.73–1.75
|
0.59
| | | |
|
Oral hygiene before treatment Good vs. Poor
|
1.58
|
1.01–2.48
|
0.043
|
1.11
|
0.68–1.83
|
0.68
|
|
Coexistence of other malignancies Yes vs. No
|
0.89
|
0.64–1.23
|
0.48
| | | |
|
Charlson comorbidity index 0–1 vs. ≥2
|
1.32
|
0.79–2.22
|
0.29
| | | |
|
Serum albumin before treatment Within normal limits vs. less than normal range
|
2.78
|
1.59–4.77
|
< 0.001
|
1.88
|
0.95–3.75
|
0.069
|
|
Hemoglobin before treatment Within normal limits vs. less than normal range
|
1.75
|
1.09–2.79
|
0.020
|
1.07
|
0.60–1.91
|
0.82
|
|
Use of sleeping pills before treatment Yes .vs No
|
0.63
|
0.41–0.98
|
0.042
|
0.75
|
0.39–1.43
|
0.38
|
|
Induction chemotherapy Yes vs. No
|
1.15
|
0.69–1.89
|
0.60
| | | |
|
Concurrent chemotherapy regimen CDDP vs. others
|
1.15
|
0.70–1.89
|
0.57
| | | |
|
Radiation technique Conventional 3D-CRT vs. IMRT
|
0.60
|
0.37–0.98
|
0.043
|
0.65
|
0.38–1.12
|
0.12
|
|
Radiation dose 70Gy vs. <70Gy
|
4.13
|
1.18–14.4
|
0.026
|
3.70
|
0.97–14.1
|
0.056
|
|
Irradiation field Local vs. whole neck
|
0.98
|
0.56–1.72
|
0.95
| | | |
|
Percutaneous endoscopic gastrostomy prior to treatment Yes vs. No
|
0.50
|
0.31–0.80
|
0.041
|
0.68
|
0.40–1.15
|
0.15
|
|
Treatment Inpatient vs. Outpatient
|
0.62
|
0.40–0.96
|
0.032
|
0.86
|
0.52–1.40
|
0.53
|
|
The worst mucositis grade during treatment 1–2 vs. 3–4
|
1.09
|
0.70–1.70
|
0.70
| | | |
|
The worst dysphagia score during treatment 1–2 vs. 3–4
|
1.39
|
0.89–2.17
|
0.15
| | | |
|
Aspiration pneumonia during treatment Yes vs. No
|
0.38
|
0.23–0.62
|
< 0.001
|
0.52
|
0.30–0.90
|
0.020
|
