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Table 2 Univariate and multivariate analysis for risk factors of aspiration pneumonia

From: Risk factors for aspiration pneumonia during concurrent chemoradiotherapy or bio-radiotherapy for head and neck cancer

Variables Univariate analysis Multivariate analysis
Odds ratio 95% CI P Odds ratio 95% CI P
Age < 70 vs. ≥70 0.94 0.56–1.59 0.82    
Gender Male vs. Female 1.32 0.65–2.68 0.45    
ECOG Performance status 0–1 vs.2–3 0.28 0.11–0.72 0.0081 0.68 0.24–1.93 0.47
BMI < 20 vs. ≥20 1.56 0.94–2.60 0.086    
Primary site Oropharynx vs. others 1.77 1.07–2.92 0.027 0.84 0.47–1.49 0.55
T-classification 1–2 vs. 3–4 0.86 0.54–1.37 0.52    
N-classification 0-2b vs. 2c-3 0.39 0.23–0.66 < 0.001 0.51 0.28–0.93 0.027
Histology SCC vs. others 1.54 0.57–4.18 0.40    
Brinkman index < 500 vs. ≥500 1.11 0.69–1.81 0.67    
Habitual alcoholic consumption Yes vs. No 1.43 0.88–2.33 0.16    
Use of ACEi or ARB Yes vs. No 1.25 0.70–2.22 0.45    
Use of PPI or H2 blocker Yes vs. No 1.39 0.86–2.22 0.18    
Oral hygiene before treatment Good vs. Poor 0.40 0.25–0.66 < 0.001 0.48 0.28–0.83 0.0076
Coexistence of other malignancies Yes vs. No 1.12 0.78–1.56 0.57    
Charlson comorbidity index 0–1 vs. ≥2 0.76 0.44–1.31 0.32    
Serum albumin before treatment Within normal limits vs. less than normal range 0.15 0.27–0.48 < 0.001 0.36 0.18–0.73 0.0015
Hemoglobin before treatment Within normal limits vs. less than normal range 0.37 0.23–0.61 < 0.001 0.78 0.43–1.43 0.42
Use of sleeping pills before treatment Yes .vs No 1.35 0.75–2.44 0.32    
Induction chemotherapy Yes vs. No 0.76 0.44–1.31 0.33    
Concurrent chemotherapy regimen CDDP vs. others 1.30 0.75–2.25 0.36    
Radiation technique Conventional 3D-CRT vs. IMRT 1.12 0.68–1.85 0.66    
Radiation dose 70Gy vs. <70Gy 0.58 0.17–2.04 0.40    
Irradiation field Local vs. whole neck 0.40 0.19–0.84 0.016 0.56 0.25–1.23 0.15
Percutaneous endoscopic gastrostomy prior to treatment Yes vs. No 1.62 0.96–2.77 0.067    
Treatment Inpatient vs. Outpatient 2.70 1.65–4.40 < 0.001 2.35 1.39–3.98 0.0015
Dysphagia score before treatment 1–2 vs. 3–4 0.56 0.30–1.03 0.062