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Table 2 Univariate and multivariate analysis for risk factors of aspiration pneumonia

From: Risk factors for aspiration pneumonia during concurrent chemoradiotherapy or bio-radiotherapy for head and neck cancer

Variables

Univariate analysis

Multivariate analysis

Odds ratio

95% CI

P

Odds ratio

95% CI

P

Age < 70 vs. ≥70

0.94

0.56–1.59

0.82

   

Gender Male vs. Female

1.32

0.65–2.68

0.45

   

ECOG Performance status 0–1 vs.2–3

0.28

0.11–0.72

0.0081

0.68

0.24–1.93

0.47

BMI < 20 vs. ≥20

1.56

0.94–2.60

0.086

   

Primary site Oropharynx vs. others

1.77

1.07–2.92

0.027

0.84

0.47–1.49

0.55

T-classification 1–2 vs. 3–4

0.86

0.54–1.37

0.52

   

N-classification 0-2b vs. 2c-3

0.39

0.23–0.66

< 0.001

0.51

0.28–0.93

0.027

Histology SCC vs. others

1.54

0.57–4.18

0.40

   

Brinkman index < 500 vs. ≥500

1.11

0.69–1.81

0.67

   

Habitual alcoholic consumption Yes vs. No

1.43

0.88–2.33

0.16

   

Use of ACEi or ARB Yes vs. No

1.25

0.70–2.22

0.45

   

Use of PPI or H2 blocker Yes vs. No

1.39

0.86–2.22

0.18

   

Oral hygiene before treatment Good vs. Poor

0.40

0.25–0.66

< 0.001

0.48

0.28–0.83

0.0076

Coexistence of other malignancies Yes vs. No

1.12

0.78–1.56

0.57

   

Charlson comorbidity index 0–1 vs. ≥2

0.76

0.44–1.31

0.32

   

Serum albumin before treatment Within normal limits vs. less than normal range

0.15

0.27–0.48

< 0.001

0.36

0.18–0.73

0.0015

Hemoglobin before treatment Within normal limits vs. less than normal range

0.37

0.23–0.61

< 0.001

0.78

0.43–1.43

0.42

Use of sleeping pills before treatment Yes .vs No

1.35

0.75–2.44

0.32

   

Induction chemotherapy Yes vs. No

0.76

0.44–1.31

0.33

   

Concurrent chemotherapy regimen CDDP vs. others

1.30

0.75–2.25

0.36

   

Radiation technique Conventional 3D-CRT vs. IMRT

1.12

0.68–1.85

0.66

   

Radiation dose 70Gy vs. <70Gy

0.58

0.17–2.04

0.40

   

Irradiation field Local vs. whole neck

0.40

0.19–0.84

0.016

0.56

0.25–1.23

0.15

Percutaneous endoscopic gastrostomy prior to treatment Yes vs. No

1.62

0.96–2.77

0.067

   

Treatment Inpatient vs. Outpatient

2.70

1.65–4.40

< 0.001

2.35

1.39–3.98

0.0015

Dysphagia score before treatment 1–2 vs. 3–4

0.56

0.30–1.03

0.062

   
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