Variables | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
Odds ratio | 95% CI | P | Odds ratio | 95% CI | P | |
Age < 70 vs. ≥70 | 0.94 | 0.56–1.59 | 0.82 |  |  |  |
Gender Male vs. Female | 1.32 | 0.65–2.68 | 0.45 |  |  |  |
ECOG Performance status 0–1 vs.2–3 | 0.28 | 0.11–0.72 | 0.0081 | 0.68 | 0.24–1.93 | 0.47 |
BMI < 20 vs. ≥20 | 1.56 | 0.94–2.60 | 0.086 |  |  |  |
Primary site Oropharynx vs. others | 1.77 | 1.07–2.92 | 0.027 | 0.84 | 0.47–1.49 | 0.55 |
T-classification 1–2 vs. 3–4 | 0.86 | 0.54–1.37 | 0.52 |  |  |  |
N-classification 0-2b vs. 2c-3 | 0.39 | 0.23–0.66 | < 0.001 | 0.51 | 0.28–0.93 | 0.027 |
Histology SCC vs. others | 1.54 | 0.57–4.18 | 0.40 |  |  |  |
Brinkman index < 500 vs. ≥500 | 1.11 | 0.69–1.81 | 0.67 |  |  |  |
Habitual alcoholic consumption Yes vs. No | 1.43 | 0.88–2.33 | 0.16 |  |  |  |
Use of ACEi or ARB Yes vs. No | 1.25 | 0.70–2.22 | 0.45 |  |  |  |
Use of PPI or H2 blocker Yes vs. No | 1.39 | 0.86–2.22 | 0.18 |  |  |  |
Oral hygiene before treatment Good vs. Poor | 0.40 | 0.25–0.66 | < 0.001 | 0.48 | 0.28–0.83 | 0.0076 |
Coexistence of other malignancies Yes vs. No | 1.12 | 0.78–1.56 | 0.57 |  |  |  |
Charlson comorbidity index 0–1 vs. ≥2 | 0.76 | 0.44–1.31 | 0.32 |  |  |  |
Serum albumin before treatment Within normal limits vs. less than normal range | 0.15 | 0.27–0.48 | < 0.001 | 0.36 | 0.18–0.73 | 0.0015 |
Hemoglobin before treatment Within normal limits vs. less than normal range | 0.37 | 0.23–0.61 | < 0.001 | 0.78 | 0.43–1.43 | 0.42 |
Use of sleeping pills before treatment Yes .vs No | 1.35 | 0.75–2.44 | 0.32 |  |  |  |
Induction chemotherapy Yes vs. No | 0.76 | 0.44–1.31 | 0.33 |  |  |  |
Concurrent chemotherapy regimen CDDP vs. others | 1.30 | 0.75–2.25 | 0.36 |  |  |  |
Radiation technique Conventional 3D-CRT vs. IMRT | 1.12 | 0.68–1.85 | 0.66 |  |  |  |
Radiation dose 70Gy vs. <70Gy | 0.58 | 0.17–2.04 | 0.40 |  |  |  |
Irradiation field Local vs. whole neck | 0.40 | 0.19–0.84 | 0.016 | 0.56 | 0.25–1.23 | 0.15 |
Percutaneous endoscopic gastrostomy prior to treatment Yes vs. No | 1.62 | 0.96–2.77 | 0.067 |  |  |  |
Treatment Inpatient vs. Outpatient | 2.70 | 1.65–4.40 | < 0.001 | 2.35 | 1.39–3.98 | 0.0015 |
Dysphagia score before treatment 1–2 vs. 3–4 | 0.56 | 0.30–1.03 | 0.062 |  |  |  |