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Table 1 Demographic and Clinicopathological Characteristics of Thyroid Carcinoma Patients according to Lymph Node Metastasis Status

From: Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study

VariancePTCFTC
LNM-negativeLNM-positiveTotalP valueLNM-negativeLNM-positiveTotalP value
Age at diagnosis (mean ± SD),y47.4 ± 13.643.8 ± 14.745.8 ± 14.2<.000148.8 ± 15.555.3 ± 16.349.6 ± 15.7<.0001
Sex   <.0001   <.0001
 Male4349 (40.3)6443 (59.7)10,792 470 (81.3)108 (18.7)578 
 Female22,389 (59.9)14,985 (40.1)37,374 1450 (90.5)153 (9.5)1603 
Race   <.0001   .004
 White22,468 (56.3)17,472 (43.7)39,940 1599 (88.7)203 (11.3)1802 
 Black1166 (64.1)654 (35.9)1820 136 (88.3)18 (11.7)154 
 API2613 (48.2)2812 (51.8)5425 000 
 AI/AN119 (38.6)189 (61.4)308 157 (80.1)39 (19.9)196 
 Unknown372 (55.3)301 (44.7)673 28 (96.6)1 (3.4)29 
Tumor size (mean ± SD),mm16.1 ± 15.223.3 ± 19.519.3 ± 17.6<.000134.7 ± 23.043.9 ± 29.035.8 ± 23.9<.0001
 0–1011,448 (72.8)4273 (27.2)15,721 146 (89.6)17 (10.4)163 
 11–208195 (52.8)7336 (47.2)15,531 352 (89.3)42 (10.7)394 
 21–405168 (43.7)6668 (56.3)11,836 808 (91.2)78 (8.8)886 
 >401507 (37.0)2568 (63.0)4075 562 (83.1)114 (16.9)676 
 Unknown420 (41.9)583 (58.1)1003 52 (83.9)10 (16.1)62 
ETE   <.0001   <.0001
 Localized23,577 (65.2)12,586 (34.8)36,163 1693 (93.0)128 (7.0)1821 
 Minora1091 (26.4)3036 (73.6)4127 59 (61.5)37 (38.5)96 
 Strap musclesb1453 (30.3)3341 (69.7)4794 68 (71.6)27 (28.4)95 
 Major neck structuresc373 (16.8)1841 (83.2)2214 63 (53.4)55 (46.6)118 
 Unknown244 (28.1)624 (71.9)868 37 (72.5)14 (27.5)51 
Laterality   .03   .55
 One side26,584 (55.6)21,270 (44.4)47,854 1914 (88.1)259 (11.9)2173 
 Bilateral154 (49.4)158 (50.6)312 6 (75.0)2 (25.0)8 
Multifocality   <.0001   <.0001
 Absent15,054 (62.4)9079 (37.6)24,133 1587 (91.4)149 (8.6)1736 
 Present11,387 (49.1)11,814 (50.9)23,201 298 (76.2)93 (23.8)391 
 Unknown297 (35.7)535 (64.3)832 35 (64.8)19 (35.2)54 
Histological Variant   <.0001    
 Adenocarcinoma14,709 (47.8)16,065 (52.2)30,774  
 Follicular variant9168 (71.5)3650 (28.5)12,818  
 Oxyphilic cell variant52 (56.5)40 (43.5)92  
 Encapsulated variant209 (76.0)66 (24.0)275  
 Columnar cell variant267 (35.6)484 (64.4)751  
 Microcarcinomad1412 (85.3)244 (14.7)1656  
 Unknown921 (51.2)879 (48.8)1800  
T Stage   <.0001   <.0001
 T1a11,146 (75.3)3652 (24.7)14,798 144 (90.6)15 (9.4)159 
 T1b7497 (56.5)5763 (43.5)13,260 342 (91.2)33 (8.8)375 
 T24641 (49.2)4801 (50.8)9442 773 (93.1)57 (6.9)830 
 T32746 (36.2)4850 (63.8)7596 551 (85.6)93 (14.4)644 
 T4373 (16.8)1842 (83.2)2215 63 (53.4)55 (46.6)118 
 Unknown335 (39.2)520 (60.8)855 47 (85.5)8 (14.5)55 
Distant metastasise   <.0001   <.0001
 No26,497 (56.1)20,698 (43.9)47,195 1856 (90.1)205 (9.9)2061 
 Yes103 (18.5)455 (81.5)558 56 (50.9)54 (49.1)110 
 Unknown138 (33.4)275 (66.6)413 8 (80.0)2 (20.0)10 
Total26,738 (55.5)21,428 (44.5)48,166 1920 (88.0)261 (12.0)2181 
  1. Abbreviations: LNM Lymph node metastasis, PTC Papillary thyroid carcinoma FTC Follicular thyroid carcinoma, API Asian or Pacific Islander, AI/AN American Indian/Alaska Native, ETE Extrathyroidal extension
  2. Note: aPericapsular soft tissue/connective tissue; bsternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles; cinvading subcutaneous soft tissues, larynx, trachea, esophagus, recurrent laryngeal nerve, prevertebral fascia, encasing carotid artery, or mediastinal vessels; dlabeled as microcarcinoma in the Surveillance Epidemiology, and End Results (SEER) database, there was no specific pathological subtype classification; eincluding the bone, brain, liver, and lung. Number of observations: 50,347