Table 1 Demographic and Clinicopathological Characteristics of Thyroid Carcinoma Patients according to Lymph Node Metastasis Status
Variance | PTC | FTC | ||||||
|---|---|---|---|---|---|---|---|---|
LNM-negative | LNM-positive | Total | P value | LNM-negative | LNM-positive | Total | P value | |
Age at diagnosis (mean ± SD),y | 47.4 ± 13.6 | 43.8 ± 14.7 | 45.8 ± 14.2 | <.0001 | 48.8 ± 15.5 | 55.3 ± 16.3 | 49.6 ± 15.7 | <.0001 |
Sex | <.0001 | <.0001 | ||||||
Male | 4349 (40.3) | 6443 (59.7) | 10,792 | 470 (81.3) | 108 (18.7) | 578 | ||
Female | 22,389 (59.9) | 14,985 (40.1) | 37,374 | 1450 (90.5) | 153 (9.5) | 1603 | ||
Race | <.0001 | .004 | ||||||
White | 22,468 (56.3) | 17,472 (43.7) | 39,940 | 1599 (88.7) | 203 (11.3) | 1802 | ||
Black | 1166 (64.1) | 654 (35.9) | 1820 | 136 (88.3) | 18 (11.7) | 154 | ||
API | 2613 (48.2) | 2812 (51.8) | 5425 | 0 | 0 | 0 | ||
AI/AN | 119 (38.6) | 189 (61.4) | 308 | 157 (80.1) | 39 (19.9) | 196 | ||
Unknown | 372 (55.3) | 301 (44.7) | 673 | 28 (96.6) | 1 (3.4) | 29 | ||
Tumor size (mean ± SD),mm | 16.1 ± 15.2 | 23.3 ± 19.5 | 19.3 ± 17.6 | <.0001 | 34.7 ± 23.0 | 43.9 ± 29.0 | 35.8 ± 23.9 | <.0001 |
0–10 | 11,448 (72.8) | 4273 (27.2) | 15,721 | 146 (89.6) | 17 (10.4) | 163 | ||
11–20 | 8195 (52.8) | 7336 (47.2) | 15,531 | 352 (89.3) | 42 (10.7) | 394 | ||
21–40 | 5168 (43.7) | 6668 (56.3) | 11,836 | 808 (91.2) | 78 (8.8) | 886 | ||
>40 | 1507 (37.0) | 2568 (63.0) | 4075 | 562 (83.1) | 114 (16.9) | 676 | ||
Unknown | 420 (41.9) | 583 (58.1) | 1003 | 52 (83.9) | 10 (16.1) | 62 | ||
ETE | <.0001 | <.0001 | ||||||
Localized | 23,577 (65.2) | 12,586 (34.8) | 36,163 | 1693 (93.0) | 128 (7.0) | 1821 | ||
Minora | 1091 (26.4) | 3036 (73.6) | 4127 | 59 (61.5) | 37 (38.5) | 96 | ||
Strap musclesb | 1453 (30.3) | 3341 (69.7) | 4794 | 68 (71.6) | 27 (28.4) | 95 | ||
Major neck structuresc | 373 (16.8) | 1841 (83.2) | 2214 | 63 (53.4) | 55 (46.6) | 118 | ||
Unknown | 244 (28.1) | 624 (71.9) | 868 | 37 (72.5) | 14 (27.5) | 51 | ||
Laterality | .03 | .55 | ||||||
One side | 26,584 (55.6) | 21,270 (44.4) | 47,854 | 1914 (88.1) | 259 (11.9) | 2173 | ||
Bilateral | 154 (49.4) | 158 (50.6) | 312 | 6 (75.0) | 2 (25.0) | 8 | ||
Multifocality | <.0001 | <.0001 | ||||||
Absent | 15,054 (62.4) | 9079 (37.6) | 24,133 | 1587 (91.4) | 149 (8.6) | 1736 | ||
Present | 11,387 (49.1) | 11,814 (50.9) | 23,201 | 298 (76.2) | 93 (23.8) | 391 | ||
Unknown | 297 (35.7) | 535 (64.3) | 832 | 35 (64.8) | 19 (35.2) | 54 | ||
Histological Variant | <.0001 | |||||||
Adenocarcinoma | 14,709 (47.8) | 16,065 (52.2) | 30,774 | – | – | – | ||
Follicular variant | 9168 (71.5) | 3650 (28.5) | 12,818 | – | – | – | ||
Oxyphilic cell variant | 52 (56.5) | 40 (43.5) | 92 | – | – | – | ||
Encapsulated variant | 209 (76.0) | 66 (24.0) | 275 | – | – | – | ||
Columnar cell variant | 267 (35.6) | 484 (64.4) | 751 | – | – | – | ||
Microcarcinomad | 1412 (85.3) | 244 (14.7) | 1656 | – | – | – | ||
Unknown | 921 (51.2) | 879 (48.8) | 1800 | – | – | – | ||
T Stage | <.0001 | <.0001 | ||||||
T1a | 11,146 (75.3) | 3652 (24.7) | 14,798 | 144 (90.6) | 15 (9.4) | 159 | ||
T1b | 7497 (56.5) | 5763 (43.5) | 13,260 | 342 (91.2) | 33 (8.8) | 375 | ||
T2 | 4641 (49.2) | 4801 (50.8) | 9442 | 773 (93.1) | 57 (6.9) | 830 | ||
T3 | 2746 (36.2) | 4850 (63.8) | 7596 | 551 (85.6) | 93 (14.4) | 644 | ||
T4 | 373 (16.8) | 1842 (83.2) | 2215 | 63 (53.4) | 55 (46.6) | 118 | ||
Unknown | 335 (39.2) | 520 (60.8) | 855 | 47 (85.5) | 8 (14.5) | 55 | ||
Distant metastasise | <.0001 | <.0001 | ||||||
No | 26,497 (56.1) | 20,698 (43.9) | 47,195 | 1856 (90.1) | 205 (9.9) | 2061 | ||
Yes | 103 (18.5) | 455 (81.5) | 558 | 56 (50.9) | 54 (49.1) | 110 | ||
Unknown | 138 (33.4) | 275 (66.6) | 413 | 8 (80.0) | 2 (20.0) | 10 | ||
Total | 26,738 (55.5) | 21,428 (44.5) | 48,166 | 1920 (88.0) | 261 (12.0) | 2181 | ||