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Table 2 Characteristics of studies included in out meta-analysis

From: Relationship of lymphovascular invasion with lymph node metastasis and prognosis in superficial esophageal carcinoma: systematic review and meta-analysis

Author Years Included Region No. Treatment Characteristic Pathology Depth of Invasion Staining Indicator (No.) Including Statistics NOS Scores
Jia (2016) [11] 2010-2015 China 93 Esophagectomy and lymphadenectomy SCC/Others M1-SM3 NM LVI(28) LNM 5
Sepesi (2010) [12] 2000-2008 USA 54 Esophagectomy and lymphadenectomy AD SM NM LVI(7) LNM 5
Leggett (2015) [7] 1995-2011 USA 269 EMR followed by ablative techniques AD LP-SM H&E LVI(53) OS 6
Huh (2017) [13] 1996-2015 Korea 275 187 Esophagectomy and 88 ER (Esophagectomy or ER) SCC M-SM H&E LVI(36) LNM 6
Zhou (2016) [14] 2008-2015 China 498 Esophagectomy with lymphadenectomy SCC M1-SM3 H&E/IHC LI(16/412) LNM 7
Moon (2014) [15] 2009-2012 Korea 104 Esophagectomy with lymphadenectomy SCC M1-SM3 H&E LVI(13) LNM 6
Mitobe (2013) [16] 1990-2009 Japan 110 106 Esophagectomy with lymphadenectomy, 4 esophagectomy follwed ER and lymphadenectomy SCC LP-SM3 IHC LI(42) LNM 6
Nentwich (2014) [17] 1994-2009 Germany 67 Esophagectomy SCC/AD SM NM LI(16/61) LNM 5
Raja (2011) [18] 1983-2010 USA 120 Esophagectomy SCC/AD SM NM LVI(26) LNM/OS 5
Nakajima (2002) [19] 1985-1995 Japan 84 Esophagectomy with lymphadenectomy SCC SM IHC LI(60) LNM 6
Choi (2011) [20] 1991-2009 Korea 190 Esophagectomy with lymphadenectomy SCC M1-SM3 H&E LVI(39) LNM 7
Tajima (2000) [21] 1968-1996 Japan 240 Esophagectomy with lymphadenectomy SCC LP-SM H&E LI(39/186) LNM 6
Chiba (2010) [22] 1992-2008 Japan 110 107 underwent esophagectomy, 3 patients underwent ER followed esophagectomy SCC M-SM IHC LI(46) LNM 6
Yamashina (2013) [8] 1995-2010 Japan 402 EMR or ESD, some patients received surgery after ER SCC EP-SM2 NM LVI(33) OS 5
Xue (2012) [23] 1990-2004 China 271 Esophagectomy SCC M2-SM3 IHC LI(51) LNM 7
Ancona (2008) [24] 1980-2006 Italy 98 Esophagectomy with lymphadenectomy SCC/AD M1-SM3 NM LI(34) LNM 5
Li (2013) [25] 2006-2011 China 189 Esophagectomy with lymphadenectomy SCC M1-SM3 NM LVI(22) LNM 5
Qi (2016) [26] 2009-2014 China 258 Esophagectomy with lymphadenectomy SCC SM H&E LVI(18) LNM/OS 6
Wang (2016) [27] 2002-2014 Japan 598 Esophagectomy with lymphadenectomy SCC M-SM H&E/IHC LI(62/228) LNM 6
Kim (2008) [28] 1994-2006 Korea 200 Esophagectomy with lymphadenectomy SCC/AD M-SM NM LI(33) LNM 5
Tanaka (2014) [9] 1988-2010 Japan 145 Esophagectomy with lymphadenectomy SCC SM1-SM3 NM LVI(84) OS 5
Zhuge (2018) [29] 2006-2016 China 175 Esophagectomy with lymphadenectomy SCC SM1-SM3 NM LVI(32) LNM 6
Xue (2018) [10] 1990-2004 China 199 Esophagectomy with lymphadenectomy SCC M2-SM3 IHC LVI(27) OS 6
  1. LVI Lymphovascular Invasion, LI Lymphatic invasion
  2. ER Endoscopic resection, EMR Endoscopic mucosal resection, ESD Endoscopic submucosal dissection
  3. SCC Squamous cell carcinoma, AD Adenocarcinoma, OS Overall survival
  4. EP Epithelium, M Mucosa, SM Submucosa, LP Lamina propria, NM Not mentioned
  5. H&E Hematoxylin-eosin, IHC Immunohistochemical