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Table 2 Characteristics of studies included in out meta-analysis

From: Relationship of lymphovascular invasion with lymph node metastasis and prognosis in superficial esophageal carcinoma: systematic review and meta-analysis

AuthorYears IncludedRegionNo.Treatment CharacteristicPathologyDepth of InvasionStainingIndicator (No.)Including StatisticsNOS Scores
Jia (2016) [11]2010-2015China93Esophagectomy and lymphadenectomySCC/OthersM1-SM3NMLVI(28)LNM5
Sepesi (2010) [12]2000-2008USA54Esophagectomy and lymphadenectomyADSMNMLVI(7)LNM5
Leggett (2015) [7]1995-2011USA269EMR followed by ablative techniquesADLP-SMH&ELVI(53)OS6
Huh (2017) [13]1996-2015Korea275187 Esophagectomy and 88 ER (Esophagectomy or ER)SCCM-SMH&ELVI(36)LNM6
Zhou (2016) [14]2008-2015China498Esophagectomy with lymphadenectomySCCM1-SM3H&E/IHCLI(16/412)LNM7
Moon (2014) [15]2009-2012Korea104Esophagectomy with lymphadenectomySCCM1-SM3H&ELVI(13)LNM6
Mitobe (2013) [16]1990-2009Japan110106 Esophagectomy with lymphadenectomy, 4 esophagectomy follwed ER and lymphadenectomySCCLP-SM3IHCLI(42)LNM6
Nentwich (2014) [17]1994-2009Germany67EsophagectomySCC/ADSMNMLI(16/61)LNM5
Raja (2011) [18]1983-2010USA120EsophagectomySCC/ADSMNMLVI(26)LNM/OS5
Nakajima (2002) [19]1985-1995Japan84Esophagectomy with lymphadenectomySCCSMIHCLI(60)LNM6
Choi (2011) [20]1991-2009Korea190Esophagectomy with lymphadenectomySCCM1-SM3H&ELVI(39)LNM7
Tajima (2000) [21]1968-1996Japan240Esophagectomy with lymphadenectomySCCLP-SMH&ELI(39/186)LNM6
Chiba (2010) [22]1992-2008Japan110107 underwent esophagectomy, 3 patients underwent ER followed esophagectomySCCM-SMIHCLI(46)LNM6
Yamashina (2013) [8]1995-2010Japan402EMR or ESD, some patients received surgery after ERSCCEP-SM2NMLVI(33)OS5
Xue (2012) [23]1990-2004China271EsophagectomySCCM2-SM3IHCLI(51)LNM7
Ancona (2008) [24]1980-2006Italy98Esophagectomy with lymphadenectomySCC/ADM1-SM3NMLI(34)LNM5
Li (2013) [25]2006-2011China189Esophagectomy with lymphadenectomySCCM1-SM3NMLVI(22)LNM5
Qi (2016) [26]2009-2014China258Esophagectomy with lymphadenectomySCCSMH&ELVI(18)LNM/OS6
Wang (2016) [27]2002-2014Japan598Esophagectomy with lymphadenectomySCCM-SMH&E/IHCLI(62/228)LNM6
Kim (2008) [28]1994-2006Korea200Esophagectomy with lymphadenectomySCC/ADM-SMNMLI(33)LNM5
Tanaka (2014) [9]1988-2010Japan145Esophagectomy with lymphadenectomySCCSM1-SM3NMLVI(84)OS5
Zhuge (2018) [29]2006-2016China175Esophagectomy with lymphadenectomySCCSM1-SM3NMLVI(32)LNM6
Xue (2018) [10]1990-2004China199Esophagectomy with lymphadenectomySCCM2-SM3IHCLVI(27)OS6
  1. LVI Lymphovascular Invasion, LI Lymphatic invasion
  2. ER Endoscopic resection, EMR Endoscopic mucosal resection, ESD Endoscopic submucosal dissection
  3. SCC Squamous cell carcinoma, AD Adenocarcinoma, OS Overall survival
  4. EP Epithelium, M Mucosa, SM Submucosa, LP Lamina propria, NM Not mentioned
  5. H&E Hematoxylin-eosin, IHC Immunohistochemical