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Table 2 Univariate Analyses of tumor-related death among 568 patients using the ENETS, 8th AJCC, 7th AJCC and m7th AJCC staging systems including four tumor stages for pNECs

From: Validation and modification of staging Systems for Poorly Differentiated Pancreatic Neuroendocrine Carcinoma

TNM staging systemsMedian OS (months)HR (95%CI)P
 II40.03.28 (0.77–13.98)0.11
 III48.02.22 (0.54–9.13)0.27
 IV7.08.92 (2.21–35.92)0.002
8th AJCC
 II138.00.70 (0.38–1.26)0.23
 III15.01.73 (0.93–3.21)0.08
 IV7.03.70 (2.26–6.06)< 0.001
7th AJCC
 II40.01.08 (0.60–1.93)0.79
 III13.02.14 (0.98–4.67)0.06
 IV7.04.36 (2.58–7.36)< 0.001
m7th AJCC
 II311.24 (0.74–2.07)0.41
 III132.31 (1.12–4.75)0.02
 IV74.70 (3.05–7.24)< 0.001
  1. Abbreviations: AJCC American Joint Committee on Cancer; ENETS European Neuroendocrine Tumor Society; m7th AJCC modified 7th AJCC; pNECs poorly differentiated pancreatic neuroendocrine carcinomas; OS overall survival; HR hazard ratio; CI confidence interval