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Table 3 Expression of PD-L1 in different histological pattern with EGFR mutation

From: Heterogeneous components of lung adenocarcinomas confer distinct EGFR mutation and PD-L1 expression

Isolated areaHistological components (%)EGFR mutation (ARMS)EGFR mutation in components (mutation, abundance%)PD-L1 TPS (%)PD-L1 differential expression
APapillary (60)L858R, T790MPapillary (L858R, 71; T790M, 9.7)30Papillary (Neg)
BAcinar (40) Acinar (Neg) Acinar (80% pos)
ALepidic (80)T790MLepidic (T790M) Microp (T790M)10Lepidic (Neg)
BMicrop (20)   Microp (50% pos)
AAcinar (50)E19del, T790MAcinar (E19del, neg; T790M, neg)70Acinar (90% Pos)
BSolid (35) Solid (E19del, 48; T790M, 9.7) Solid (70% Pos)
CMicrop (15) Microp (E19del, neg;; T790M, neg) Microp (Neg)
AAcinar (60)E19del, T790MAcinar (E19del, neg; T790M, neg)00
BMicrop (40) Microp (E19del, 15.6; T790M, 9.5)  
ALepidic (100)L858R, T790MLepidic (L858R, 5.7; T790M, 3.6)00
ASolid (70)L858R, T790MSolid (L858R, Neg; T790M, Neg)80Solid (90% pos)
BMicrop (30) Microp (L858R, 66.1; T790M, 65.4)  
AAcinar (65)L858R, T790MAcinar (L858R, neg; T790M, neg)70Acinar (Pos)
BPapillary (35) Papillary (L858R, 61.7; T790M, 25.8) Papillary (10% pos)
APapillaryL858R, T790MPapillary (L858R, 1.6; T790M, 1.2)00
APapillaryL858R, T790MPapillary (L858R, 50.9; T790M, 51.7)00
APapillaryL858R, T790MPapillary (L858R, 76.8; T790M, 85.3)00
APapillaryE19del, T790MPapillary (E19del, 44.3; T790M, 17.3)00
AAcinarL858R, T790MAcinar (L858R, 10.6; T790M, 9.94)100Acinar (Pos)
AAcinarL858R, T790MAcinar (L858R, 5.7; T790M, 3.6)00
AMicrop (90)L858R, T790MMicrop (L858R, 10.5; T790M, 11.6)00
BAcinar (10) Acinar (L858R, neg; T790M, neg)  
AAcinarE19del, T790MAcinar (E19del, 8.5; T790M, 6.3)00
AAcinar (40)L858R, T790MAcinar (L858R, 17.3; T790M, 4.3)30Acinar (Pos)
BPapillary (60) Papillary (L858R, 56.3; T790M, 13.6) Papillary (Neg)
APapillary (65)E19del, T790MPapillary (E19del, 22.7; T790M, 33.6)40Papillary (20% pos)
BAcinar (30) Acinar (E19del, neg; T790M, neg) Acinar (Pos)
CMicrop (5) Microp (E19del, 5.4; T790M, 1.7) Microp (Neg)
ALepidicL858R, T790MLepidic (L858R, 33.5; T790M, 30.5)00