Table 3 Expression of PD-L1 in different histological pattern with EGFR mutation
From: Heterogeneous components of lung adenocarcinomas confer distinct EGFR mutation and PD-L1 expression
Isolated area | Histological components (%) | EGFR mutation (ARMS) | EGFR mutation in components (mutation, abundance%) | PD-L1 TPS (%) | PD-L1 differential expression |
|---|---|---|---|---|---|
A | Papillary (60) | L858R, T790M | Papillary (L858R, 71; T790M, 9.7) | 30 | Papillary (Neg) |
B | Acinar (40) | Â | Acinar (Neg) | Â | Acinar (80% pos) |
A | Lepidic (80) | T790M | Lepidic (T790M) Microp (T790M) | 10 | Lepidic (Neg) |
B | Microp (20) | Â | Â | Â | Microp (50% pos) |
A | Acinar (50) | E19del, T790M | Acinar (E19del, neg; T790M, neg) | 70 | Acinar (90% Pos) |
B | Solid (35) | Â | Solid (E19del, 48; T790M, 9.7) | Â | Solid (70% Pos) |
C | Microp (15) | Â | Microp (E19del, neg;; T790M, neg) | Â | Microp (Neg) |
A | Acinar (60) | E19del, T790M | Acinar (E19del, neg; T790M, neg) | 0 | 0 |
B | Microp (40) | Â | Microp (E19del, 15.6; T790M, 9.5) | Â | Â |
A | Lepidic (100) | L858R, T790M | Lepidic (L858R, 5.7; T790M, 3.6) | 0 | 0 |
A | Solid (70) | L858R, T790M | Solid (L858R, Neg; T790M, Neg) | 80 | Solid (90% pos) |
B | Microp (30) | Â | Microp (L858R, 66.1; T790M, 65.4) | Â | Â |
A | Acinar (65) | L858R, T790M | Acinar (L858R, neg; T790M, neg) | 70 | Acinar (Pos) |
B | Papillary (35) | Â | Papillary (L858R, 61.7; T790M, 25.8) | Â | Papillary (10% pos) |
A | Papillary | L858R, T790M | Papillary (L858R, 1.6; T790M, 1.2) | 0 | 0 |
A | Papillary | L858R, T790M | Papillary (L858R, 50.9; T790M, 51.7) | 0 | 0 |
A | Papillary | L858R, T790M | Papillary (L858R, 76.8; T790M, 85.3) | 0 | 0 |
A | Papillary | E19del, T790M | Papillary (E19del, 44.3; T790M, 17.3) | 0 | 0 |
A | Acinar | L858R, T790M | Acinar (L858R, 10.6; T790M, 9.94) | 100 | Acinar (Pos) |
A | Acinar | L858R, T790M | Acinar (L858R, 5.7; T790M, 3.6) | 0 | 0 |
A | Microp (90) | L858R, T790M | Microp (L858R, 10.5; T790M, 11.6) | 0 | 0 |
B | Acinar (10) | Â | Acinar (L858R, neg; T790M, neg) | Â | Â |
A | Acinar | E19del, T790M | Acinar (E19del, 8.5; T790M, 6.3) | 0 | 0 |
A | Acinar (40) | L858R, T790M | Acinar (L858R, 17.3; T790M, 4.3) | 30 | Acinar (Pos) |
B | Papillary (60) | Â | Papillary (L858R, 56.3; T790M, 13.6) | Â | Papillary (Neg) |
A | Papillary (65) | E19del, T790M | Papillary (E19del, 22.7; T790M, 33.6) | 40 | Papillary (20% pos) |
B | Acinar (30) | Â | Acinar (E19del, neg; T790M, neg) | Â | Acinar (Pos) |
C | Microp (5) | Â | Microp (E19del, 5.4; T790M, 1.7) | Â | Microp (Neg) |
A | Lepidic | L858R, T790M | Lepidic (L858R, 33.5; T790M, 30.5) | 0 | 0 |