Fig. 1
From: Heterogeneous components of lung adenocarcinomas confer distinct EGFR mutation and PD-L1 expression
The typical cases for PD-L1 TPS. a PD-L1 was diffusely expressed in tumor cells. The TPS was almost 100% (× 200). b The TPS was 100% in solid area (blue arrow), but negative in acinar components (red arrow) (× 200). c The PD-L1 TPS was 70% with heterogeneous expression in the parenchyma with a single component; high TPS. Patchy positive staining was found in a solid area against stromal constituents (× 100). d Strong positive reaction to PD-L1 was stained in the peripheral cancer cells (red arrow) against to the stromal immune lymphocytes (asterisk) (× 200). TPS, tumor proportion score