Table 5 Median Biomarker Concentrations and P-Value Using the Training Set

CA125

26.4

[13.7–41.7]

13.6

[6.9–36.7]

0.073

CEA

2884.4

[1815.9–5573.8]

2115.3

[1194.8–3242.2]

0.003

CXCL9-MIG

4378.2

[2604.0–6844.5]

908.0

[539.0–1965.8]

<  0.001

CYFRA-21-1

5354.8

[3429.5–8090.4]

5088.3

[2939.9–9770.1]

0.026

GRO

2890.0-

[2076.9–4178.0]

874.4

[507.5–1790.2]

<  0.001

HGF

869.4

[643.9–1647.1]

476.3

[271.9–1177.1]

0.006

IL-10

22.8

[11.7–38.2]

23.8

[14.0–45.8]

0.525

IL-12p70

21.1

[15.5–27.0]

19.9

[16.5–127.4]

0.082

IL-16

693.6

[345.1–1458.7]

717.5

[298.8–1469.4]

0.902

IL-2

11.5

[10.9–16.6]

33.8

[19.7–52.1]

0.005

IL-4

41.7

[25.3–51.6]

33.3

[22.5–50.3]

0.902

IL-5

17.9

[15.7–23.5]

28.7

[12.8–46.8]

0.188

IL-7

10.6

[10.6–10.6]

34.9

[18.9–61.1]

NA

IL-8

126.3

[44.5–323.8]

23.6

[15.9–42.3]

<  0.001

IL-9

11.9

[11.0–20.7]

22.3

[15.2–42.6]

0.016

Leptin

30,408.0

[16,682.6–45,886.3]

22,190.7

[8684.4–54,863.7]

0.224

LIF

45.5

[30.5–79.3]

39.6

[27.1–82.3]

0.511

MCP-1

530.2

[391.363–721.512]

372.8

[279.7–462.0]

<  0.001

MIF

865.6

[453.6–1501.3]

395.0

[196.7–1274.8]

0.752

MMP-7

1978.3

[1184.2–3190.33]

3585.2

[2671.9–5080.6]

<  0.001

MMP-9

93,587.2

[62,827.2–124,300.6]

12,593.8

[8856.8–19,799.6]

<  0.001

MPO

353,987.8

[246,376.2–616,739.2]

117,658.8

[69,768.5–212,726.3]

<  0.001

NSE

7273.5

[3852.3–10,487.8]

6576.1

[3806.6–46,981.4]

<  0.001

PDGF AB/BB

25,169.6

[21,611.8–30,055.0]

41,800.6

[26,115.3–53,016.0]

<  0.001

RANTES

105,356.2

[79,497.9–155,040.2]

38,458.4

[23,423.8–112,641.5]

0.003

Resistin

35,145.6

[25,185.8–53,466.7]

12,966.2

[9521.2–17,533.1]

<  0.001

SAA

6.55e7

[2.52e7–1.2e8]

8.5e6

[4.175e6–1.9825e7]

<  0.001

sCD40L

381.8

[155.9–752.5]

219.9

[110.285–628.7]

0.018

sEGFR

654.9

[544.0–1175.5]

936.5

[543.2–1943.2]

<  0.001

sFasL

229.8

[78.2–498.2]

263.7

[135.9–573.4]

0.03

sICAM-1

150,304.6

[123,699.9–187,843.8]

145,329.4

[117,164.7–182,796.7]

0.519

sTNFRII

15,477.5

[11,712.9–20,103.6]

5818.1

[4574.8–7295.3]

<  0.001

TNFRI

2514.8

[1748.7–3743.5]

619.5

[413.9–860.2]

<  0.001