Variable | Univariate | Multivariate | ||
---|---|---|---|---|
HR(95% CI) | P value | HR(95% CI) | P value | |
Age (year) | ||||
<50 | 1 | 1 | ||
≥ 50 | 1.598(1.147–2.226) | 0.006 | 1.264(0.887–1.802) | 0.195 |
FIGO stage | ||||
I-II | 1 | 1 | ||
III-IV | 3.794(2.454–5.864) | <0.001 | 5.004(2.951–8.485) | <0.001 |
Histological grade | ||||
Low | 1 | 1. | ||
High | 1.613(1.073–2.425) | 0.022 | 1.302(0.823–2.059) | 0.259 |
Lymph node invasion | ||||
Negative | 1 | 1 | ||
Positive | 2.583(1.759–3.795) | <0.001 | 1.042(0.642–1.694) | 0.867 |
Tumor residual (cm) | ||||
Optimal(≤1) | 1 | 1 | ||
Sub-optimal(>1) | 4.183(2.845–6.149) | <0.001 | 3.182(1.970–5.140) | <0.001 |
CA125 level (U/mL) | ||||
≤ 35 | 1 | 1 | ||
>35 | 4.360(1.779–10.681) | 0.001 | 1.142(0.411–3.168) | 0.799 |
Severity of CIN | ||||
Mild versus Absence | 0.224(0.128–0.393) | <0.001 | 0.512(0.269–0.975) | 0.042 |
Sever versus Absence | 0.211(0.112–0.397) | <0.001 | 0.493(0.246–0.989) | 0.046 |
Mild versus Sever | 1.060(0.708–1.588) | 0.776 | 1.039(0.671–1.608) | 0.864 |
Timing of CIN | ||||
Early onset | 1 | 1 | ||
Non-early onset | 3.696(2.593–5.268) | <0.001 | 6.713(4.295–10.492) | <0.001 |