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Table 5 Univariate and multivariate analysis for the association between clinical characteristics and overall survival

From: Early onset neutropenia: a useful predictor of chemosensitivity and favorable prognosis in patients with serous ovarian cancer

VariableUnivariate Multivariate 
 HR(95% CI)P valueHR(95% CI)P value
Age (year)
 <501 1 
  ≥ 501.598(1.147–2.226)0.0061.264(0.887–1.802)0.195
FIGO stage
 I-II1 1 
 III-IV3.794(2.454–5.864)<0.0015.004(2.951–8.485)<0.001
Histological grade
 Low1 1. 
 High1.613(1.073–2.425)0.0221.302(0.823–2.059)0.259
Lymph node invasion
 Negative1 1 
 Positive2.583(1.759–3.795)<0.0011.042(0.642–1.694)0.867
Tumor residual (cm)
 Optimal(≤1)1 1 
 Sub-optimal(>1)4.183(2.845–6.149)<0.0013.182(1.970–5.140)<0.001
CA125 level (U/mL)
  ≤ 351 1 
 >354.360(1.779–10.681)0.0011.142(0.411–3.168)0.799
Severity of CIN
 Mild versus Absence0.224(0.128–0.393)<0.0010.512(0.269–0.975)0.042
 Sever versus Absence0.211(0.112–0.397)<0.0010.493(0.246–0.989)0.046
 Mild versus Sever1.060(0.708–1.588)0.7761.039(0.671–1.608)0.864
Timing of CIN
 Early onset1 1 
 Non-early onset3.696(2.593–5.268)<0.0016.713(4.295–10.492)<0.001