Table 5 Univariate and multivariate analysis for the association between clinical characteristics and overall survival

 <50

1

1

  ≥ 50

1.598(1.147–2.226)

0.006

1.264(0.887–1.802)

0.195

 I-II

1

1

 III-IV

3.794(2.454–5.864)

<0.001

5.004(2.951–8.485)

<0.001

 Low

1

1.

 High

1.613(1.073–2.425)

0.022

1.302(0.823–2.059)

0.259

 Negative

1

1

 Positive

2.583(1.759–3.795)

<0.001

1.042(0.642–1.694)

0.867

 Optimal(≤1)

1

1

 Sub-optimal(>1)

4.183(2.845–6.149)

<0.001

3.182(1.970–5.140)

<0.001

  ≤ 35

1

1

 >35

4.360(1.779–10.681)

0.001

1.142(0.411–3.168)

0.799

 Mild versus Absence

0.224(0.128–0.393)

<0.001

0.512(0.269–0.975)

0.042

 Sever versus Absence

0.211(0.112–0.397)

<0.001

0.493(0.246–0.989)

0.046

 Mild versus Sever

1.060(0.708–1.588)

0.776

1.039(0.671–1.608)

0.864

 Early onset

1

1

 Non-early onset

3.696(2.593–5.268)

<0.001

6.713(4.295–10.492)

<0.001