Table 1 Characteristics of patients in the study population
Characteristic | EU5a N = 813 | France N = 146 | Germany N = 175 | Italy N = 173 | Spain N = 141 | UK N = 173 |
|---|---|---|---|---|---|---|
Median age at diagnosis, years (IQR) | 66 (58–74) | 65 (57–73) | 68 (60–74) | 65 (57–72) | 66 (61–74) | 65 (57–75) |
Male, n (%) | 477 (59) | 83 (57) | 106 (61) | 99 (57) | 85 (60) | 103 (60) |
SCT during total at-risk period, n (%)b | 317 (39) | 64 (44) | 58 (33) | 73 (42) | 49 (35) | 65 (38) |
ISS stage at diagnosis, n (%) | ||||||
 1 | 120 (15) | 22 (15) | 23 (13) | 28 (16) | 27 (19) | 22 (13) |
 2 | 282 (35) | 46 (32) | 49 (28) | 56 (32) | 58 (41) | 75 (43) |
 3 | 380 (47) | 74 (51) | 95 (54) | 78 (45) | 51 (36) | 71 (41) |
 Unknown | 31 (4) | 3 (2) | 8 (5) | 11 (6) | 5 (4) | 5 (3) |
ECOG performance status at 1 L initiation, n (%) | ||||||
 0 | 138 (17) | 11 (8) | 34 (19) | 43 (25) | 19 (14) | 36 (21) |
 1 | 467 (57) | 86 (59) | 110 (63) | 84 (49) | 77 (55) | 103 (60) |
 2 | 181 (22) | 44 (30) | 27 (15) | 43 (25) | 37 (26) | 26 (15) |
 ≥ 3 | 20 (3) | 5 (3) | 3 (2) | 3 (2) | 7 (5) | 2 (1) |
 Unknown | 8 (1) | 0 | 1 (1) | 0 | 1 (1) | 6 (4) |
Circumstances that led to MM diagnosis, n (%) | ||||||
 Bone pain | 513 (63) | 97 (66) | 109 (62) | 96 (56) | 95 (67) | 111 (64) |
 HC | 174 (21) | 30 (21) | 29 (17) | 30 (17) | 30 (21) | 52 (30) |
 VF | 188 (23) | 37 (25) | 45 (26) | 42 (24) | 22 (16) | 35 (20) |
 OF | 34 (4) | 4 (3) | 6 (3) | 13 (8) | 6 (4) | 6 (4) |
 SCC | 29 (4) | 5 (3) | 4 (2) | 8 (5) | 4 (3) | 7 (4) |
 ≥ 1 bone-related problemc | 634 (78) | 117 (80) | 135 (77) | 128 (74) | 110 (78) | 137 (79) |
 ≥ 1 HC, VF, OF or SCC | 359 (44) | 67 (46) | 71 (41) | 79 (46) | 56 (40) | 79 (46) |
 ≥ 1 VF, OF or SCC | 233 (29) | 45 (31) | 52 (30) | 58 (34) | 30 (21) | 42 (24) |
 Renal impairment | 187 (23) | 29 (20) | 55 (31) | 25 (15) | 26 (18) | 49 (28) |
Presentation at the initiation of 1 L, n (%) | ||||||
 ≥ 2 bone lesions | 598 (74) | 111 (76) | 138 (79) | 127 (73) | 96 (68) | 118 (68) |