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Table 2 Univariate and multivariate analysis of IL-36 s and clinicopathological factors affecting survival of patients with CRC

From: IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer?

CharacteristicsNo. PtUnivariate analysisMultivariate analysis
HR (95% CI)P valueHR (95% CI)P value
IL-36α 0.31 (0.13–0.69)0.0040.37 (0.16–0.87)0.02
High39/79    
Low40/79    
IL-36β 1.02 (0.48–2.18)NS  
High39/79    
Low40/79    
IL-36γ 2.33 (1.05–5.16)0.042.18 (0.95–5.04)NS
High39/79    
Low40/79    
Gender 1.02 (0.45–2.27)NS  
Male52/79    
Female27/79    
Age (years) 1.70 (0.78–3.70)NS2.46 (1.04–5.83)0.04
< 7038/79    
≥7041/79    
Position 1.09 (0.46–2.60)NS  
Right-sided22/79    
Left-sided57/79    
Size (diameter, cm) 1.84 (0.80–4.21)NS  
≤563/79    
> 516/79    
Lymph node metastasis 2.87 (1.31–6.28)0.0080.78 (0.16–3.72)NS
No45/79    
Yes34/79    
Differentiation 1.78 (0.71–4.48)NS  
Well1/79    
Moderate66/79    
Poor12/79    
Invasion depth 3.30 (1.38–7.87)0.0073.47 (1.34–8.99)0.01
T12/79    
T214/79    
T313/79    
T450/79    
TNM 2.47 (1.46–4.18)0.0012.54 (0.74–8.69)NS
I12/79    
II32/79    
III32/79    
IV3/79    
  1. HR hazard ratio, CI confidence interval, P values for Cox proportional hazards regression analysis