Table 2 Univariate and multivariate analysis of IL-36 s and clinicopathological factors affecting survival of patients with CRC

IL-36α

0.31 (0.13–0.69)

0.004

0.37 (0.16–0.87)

0.02

High

39/79

Low

40/79

IL-36β

1.02 (0.48–2.18)

NS

High

39/79

Low

40/79

IL-36γ

2.33 (1.05–5.16)

0.04

2.18 (0.95–5.04)

NS

High

39/79

Low

40/79

Gender

1.02 (0.45–2.27)

NS

Male

52/79

Female

27/79

Age (years)

1.70 (0.78–3.70)

NS

2.46 (1.04–5.83)

0.04

< 70

38/79

≥70

41/79

Position

1.09 (0.46–2.60)

NS

Right-sided

22/79

Left-sided

57/79

Size (diameter, cm)

1.84 (0.80–4.21)

NS

≤5

63/79

> 5

16/79

Lymph node metastasis

2.87 (1.31–6.28)

0.008

0.78 (0.16–3.72)

NS

No

45/79

Yes

34/79

Differentiation

1.78 (0.71–4.48)

NS

Well

1/79

Moderate

66/79

Poor

12/79

Invasion depth

3.30 (1.38–7.87)

0.007

3.47 (1.34–8.99)

0.01

T1

2/79

T2

14/79

T3

13/79

T4

50/79

TNM

2.47 (1.46–4.18)

0.001

2.54 (0.74–8.69)

NS

I

12/79

II

32/79

III

32/79

IV

3/79