Table 2 Associations between molecular subtypes and clinicopathologic variables in the development cohort
From: Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations
Variable | N | Overall | sTRU (n = 34) | sPP (n = 43) | sPI (n = 46) | EGFR/TP53 (n = 26) | KRAS/TP53 (n = 34) | Non-TRUPPPI (n = 21) | No mutation (n = 29) | P |
|---|---|---|---|---|---|---|---|---|---|---|
Age, mean (standard deviation), y | 233 | 64.8 (10.9) | 67.3 (10.6) | 67.2 (9.0) | 65.3 (9.3) | 56.9 (12.6) | 64.3 (7.9) | 67.5 (12.5) | 62.9 (13.6) | 0.005 |
Sex, n (%) | 233 | Â | Â | Â | Â | Â | Â | Â | Â | 0.075 |
 Female |  | 127 (54.5) | 20 (58.8) | 27 (62.8) | 17 (37.0) | 17 (65.4) | 20 (58.8) | 8 (38.1) | 18 (62.1) |  |
 Male |  | 106 (45.5) | 14 (41.2) | 16 (37.2) | 29 (63.0) | 9 (34.6) | 14 (41.2) | 13 (61.9) | 11 (37.9) |  |
FISH, n (%) | 226 | Â | Â | Â | Â | Â | Â | Â | Â | 0.544 |
 Negative |  | 206 (91.2) | 27 (81.8) | 37 (88.1) | 43 (93.5) | 23 (92.0) | 30 (93.8) | 20 (95.2) | 26 (96.3) |  |
 Positive |  | 20 (8.8) | 6 (18.2) | 5 (11.9) | 3 (6.5) | 2 (8.0) | 2 (6.2) | 1 (4.8) | 1 (3.7) |  |
Race/ethnicity, n (%) | 232 | Â | Â | Â | Â | Â | Â | Â | Â | 0.041a |
 Asian |  | 23 (9.9) | 8 (23.5) | 0 (0.0) | 5 (10.9) | 5 (19.2) | 1 (3.0) | 2 (9.5) | 2 (6.9) |  |
 Black |  | 16 (6.9) | 3 (8.8) | 2 (4.7) | 5 (10.9) | 1 (3.8) | 2 (6.1) | 2 (9.5) | 1 (3.4) |  |
 White |  | 175 (75.4) | 20 (58.8) | 37 (86.0) | 33 (71.7) | 15 (57.7) | 29 (87.9) | 16 (76.2) | 25 (86.2) |  |
 Hispanic |  | 18 (7.8) | 3 (8.8) | 4 (9.3) | 3 (6.5) | 5 (19.2) | 1 (3.0) | 1 (4.8) | 1 (3.4) |  |
Smoking, n (%) | 232 |  |  |  |  |  |  |  |  | < 0.001a |
 Current |  | 62 (26.7) | 5 (14.7) | 12 (27.9) | 14 (31.1) | 3 (11.5) | 19 (55.9) | 5 (23.8) | 4 (13.8) |  |
 Former |  | 115 (49.6) | 11 (32.4) | 26 (60.5) | 25 (55.6) | 11 (42.3) | 15 (44.1) | 14 (66.7) | 13 (44.8) |  |
 Never |  | 55 (23.7) | 18 (52.9) | 5 (11.6) | 6 (13.3) | 12 (46.2) | 0 (0.0) | 2 (9.5) | 12 (41.4) |  |
Aneuploidy, n (%) | 206 | Â | Â | Â | Â | Â | Â | Â | Â | 0.025 |
 No |  | 46 (22.3) | 11 (35.5) | 9 (23.1) | 9 (20.9) | 10 (40.0) | 3 (12.0) | 3 (15.8) | 1 (4.2) |  |
 Yes |  | 160 (77.7) | 20 (64.5) | 30 (76.9) | 34 (79.1) | 15 (60.0) | 22 (88.0) | 16 (84.2) | 23 (95.8) |  |