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Table 2 Associations between molecular subtypes and clinicopathologic variables in the development cohort

From: Simplified molecular classification of lung adenocarcinomas based on EGFR, KRAS, and TP53 mutations

VariableNOverallsTRU (n = 34)sPP (n = 43)sPI
(n = 46)
EGFR/TP53 (n = 26)KRAS/TP53 (n = 34)Non-TRUPPPI (n = 21)No mutation
(n = 29)
P
Age, mean (standard deviation), y23364.8 (10.9)67.3 (10.6)67.2 (9.0)65.3 (9.3)56.9 (12.6)64.3 (7.9)67.5 (12.5)62.9 (13.6)0.005
Sex, n (%)233        0.075
 Female 127 (54.5)20 (58.8)27 (62.8)17 (37.0)17 (65.4)20 (58.8)8 (38.1)18 (62.1) 
 Male 106 (45.5)14 (41.2)16 (37.2)29 (63.0)9 (34.6)14 (41.2)13 (61.9)11 (37.9) 
FISH, n (%)226        0.544
 Negative 206 (91.2)27 (81.8)37 (88.1)43 (93.5)23 (92.0)30 (93.8)20 (95.2)26 (96.3) 
 Positive 20 (8.8)6 (18.2)5 (11.9)3 (6.5)2 (8.0)2 (6.2)1 (4.8)1 (3.7) 
Race/ethnicity, n (%)232        0.041a
 Asian 23 (9.9)8 (23.5)0 (0.0)5 (10.9)5 (19.2)1 (3.0)2 (9.5)2 (6.9) 
 Black 16 (6.9)3 (8.8)2 (4.7)5 (10.9)1 (3.8)2 (6.1)2 (9.5)1 (3.4) 
 White 175 (75.4)20 (58.8)37 (86.0)33 (71.7)15 (57.7)29 (87.9)16 (76.2)25 (86.2) 
 Hispanic 18 (7.8)3 (8.8)4 (9.3)3 (6.5)5 (19.2)1 (3.0)1 (4.8)1 (3.4) 
Smoking, n (%)232        < 0.001a
 Current 62 (26.7)5 (14.7)12 (27.9)14 (31.1)3 (11.5)19 (55.9)5 (23.8)4 (13.8) 
 Former 115 (49.6)11 (32.4)26 (60.5)25 (55.6)11 (42.3)15 (44.1)14 (66.7)13 (44.8) 
 Never 55 (23.7)18 (52.9)5 (11.6)6 (13.3)12 (46.2)0 (0.0)2 (9.5)12 (41.4) 
Aneuploidy, n (%)206        0.025
 No 46 (22.3)11 (35.5)9 (23.1)9 (20.9)10 (40.0)3 (12.0)3 (15.8)1 (4.2) 
 Yes 160 (77.7)20 (64.5)30 (76.9)34 (79.1)15 (60.0)22 (88.0)16 (84.2)23 (95.8) 
  1. sTRU Simplified terminal respiratory unit, sPP Simplified proximal-proliferative, sPI Simplified proximal-inflammatory, non-TRUPPPI Mutated in genes other than EGFR, KRAS, and TP53, FISH Fluorescence in situ hybridization
  2. P values are based on Fisher exact test for categorical variables and Kruskal-Wallis rank-sum test for continuous variables
  3. aFisher exact test with Monte Carlo simulation