Table 4 Additional outcome variables

Alyami et al. [27]

2 (n = 73)^a

NR

CTCAE reported

Yes^c

No

No

Yes

PCI

Time frame (days)

30

Grade 1-2

NR

Grade 3-4

16

Grade 5

5

Demtröder et al. [28]

3 (n = 17)^a

NR

CTCAE reported

Yes^d

No

No

Yes

TRG

Time frame (days)

NR

Grade 1-2

12

Grade 3-4

4

Grade 5

0

Falkenstein et al. [29]

1 (n = 13)^a,b

NR

CTCAE reported

Yes^d

No

No

Yes

TRG, PCI

Time frame (days)

NR

Grade 1-2

9

Grade 3-4

0

Grade 5

0

Graversen et al. [30]

3 (n = 5)^a

3 (n = 1)^a

CTCAE reported

Yes

No

No

Yes

PRGS, RECIST

Time frame (days)

NR

Grade 1-2

NR

Grade 3-4

NR

Grade 5

0

Hilal et al. [31]

NR

NR

CTCAE reported

No

No

No

No

NR

Khomyakov et al. [24]

1 (n = 31)^a

1 (n = 31)^a

CTCAE reported

Yes^d

-

Yes

Yes

PRGS

Time frame (days)

30

30

Grade 1-2

3

3

Grade 3-4

1

1

Grade 5

0

0

Khosrawipour et al. [32]

1.5 (n = 20)^a,b

1 (n = 6)^a

CTCAE reported

Yes^d

Yes

Yes

Yes

TRG, PCI

Time frame (days)

NR

NR

NR

Grade 1-2

6

3

3

Grade 3-4

0

0

0

Grade 5

1

1

0

Nadiradze et al. [33]

2 (n = 24)^a

NR

CTCAE reported

Yes^d

No

No

Yes

Unspecified histological regression

Time frame (days)

NR

Grade 1-2

15

Grade 3-4

7

Grade 5

2

Reymond et al. [34]^a

4 (3)^a

7 (n = 1)^a

CTCAE reported

Yes^d

Yes

Yes

Yes

PRGS, RECIST

Time frame (days)

NR

NR

NR

Grade 1-2

3

2

1

Grade 3-4

0

0

0

Grade 5

0

0

0

Robella et al. [26]

3 (n = 14)^a

3 (n = 13)^a

CTCAE reported

Yes^d

No

No

No

NR

Time frame (days)

NR

Grade 1-2

14

Grade 3-4

0

Grade 5

0

Farinha et al. [35]

NR

NR

CTCAE reported

No

No

No

No

NR

Hübner et al. [36]

NR

NR

CTCAE reported

No

No

No

No

NR