Development and validation of a preoperative nomogram for predicting survival of patients with locally advanced prostate cancer after radical prostatectomy

Table 1 Descriptive characteristics of 14,185 locally advanced prostate cancer patients undergoing radical prostatectomy between 2010 and 2016 from the Surveillance Epidemiology and End Results database. Primary 14,185 patients were randomly divided into 2 cohorts: training cohort and validation cohort

Variable	Primary Cohort (n = 14,185)		Training Cohort (n = 9932)		Validation Cohort (n = 4253)		P-value
Variable	Number	%	Number	%	Number	%	P-value
Age							0.131
< 50	514	3.6	356	3.6	158	3.7
50–59	4092	28.9	2907	29.3	1185	27.9
60–69	7460	52.6	5163	52.0	2297	54.0
> 69	2119	14.9	1506	15.2	613	14.4
Race							0.658
White	11,445	80.7	8033	80.9	3412	80.2
Black	1852	13.0	1282	12.9	570	13.4
Other^a	888	6.3	617	6.2	271	6.4
Marital Status							0.501
Married	10,429	73.5	7289	73.4	3140	73.8
Single^b	3001	21.2	2100	21.1	901	21.2
Unknown	755	5.3	543	5.5	212	5.0
T stage							0.019
T1–2	290	2.0	185	1.9	105	2.5
T3–4	13,895	98.0	9747	98.1	4148	97.5
N stage							0.077
N0	12,215	86.1	8586	86.4	3629	85.3
N1	1970	13.9	1346	13.6	624	14.7
PSA level (ng/ml)							0.012
≤ 10	9447	66.6	6682	67.3	2765	65.0
10–20	3043	21.5	2066	20.8	977	23.0
> 20	1695	11.9	1184	11.9	511	12.0
GS biopsy							0.402
≤ 6	2142	15.1	1510	15.2	632	14.9
7 (3 + 4)	4571	32.2	3234	32.6	1337	31.4
7 (4 + 3)	3015	21.3	2080	20.9	935	22.0
8	2436	17.2	1684	17.0	752	17.7
≥ 9	2021	14.2	1424	14.3	597	14.0
% positive core biopsy							0.638
00–25%	2986	21.1	2088	21.0	898	21.1
25–50%	4982	35.1	3515	35.4	1467	34.5
50–75%	3008	21.2	2081	21.0	927	21.8
75–100%	3209	22.6	2248	22.6	961	22.6
AJCC staging system							0.140
IIIB	10,820	76.3	7591	76.4	3229	75.9
IIIC	1395	9.8	995	10.0	400	9.4
IVA	1970	13.9	1346	13.6	624	14.7

ISSN: 1471-2407