The effect of renal function change on renal cell carcinoma patients with tumor thrombus after nephrectomy and thrombectomy: a large Chinese center experience

Table 2 Linear regression analysis of absolute change in eGFR

Variables	Univariate analysis			Multivariate analysis
Variables	B	95%CI	P	B	95%CI	P
Gender (female vs. male)	5.724	−3.977-15.426	0.245
Age	−0.208	− 0.599-0.183	0.295
Body mass index	0.105	−1.090-1.301	0.862
ASA classification	−6.273	−15.458-2.912	0.179
Side (right vs. left)	1.175	−7.626-9.975	0.792
Tumor diameter	0.975	−0.228-2.178	0.111
Tumor thrombus grade	0.521	−3.013-4.055	0.771
Preoperative serum creatinine	0.079	0.027–0.132	0.003^*	–	–	–
Preoperative eGFR	−0.476	−0.653--0.299	< 0.001^*	−0.455	− 0.631--0.278	< 0.001^*
Operation approach (open vs. laparoscopy)	2.11	−6.387-10.607	0.624
Operation time	0.022	−0.013-0.056	0.213
Pathological type (non-clear cell carcinoma vs. clear cell carcinoma)	14.612	2.964–26.260	0.014^*	11.416	0.658–22.174	0.038^*
Vascular wall invasion (present vs. absent)	6.462	−2.135-15.058	0.139
Lymphatic vascular invasion (present vs. absent)	−4.479	−14.733-5.775	0.389
Perinephric tissues invasion (present vs. absent)	−2.692	−11.876-6.491	0.563
Renal pelvis invasion (present vs. absent)	7.211	−2.872-17.293	0.16
Necrosis (present vs. absent)	−1.846	−10.338-6.646	0.668
Sarcomatoid differentiation (present vs. absent)	−1.769	−13.193-9.655	0.76

eGFR estimated glomerular filtration rate, ISUP International Society of Urological Pathology; *p<0.05

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