Comparing three induction chemotherapy regimens for patients with locoregionally advanced nasopharyngeal carcinoma based on TNM stage and plasma Epstein–Barr virus DNA level

Table 5 Grade 3–4 acute toxicities due to IC between the three arms

Adverse event (toxicity grade)	TPF(n = 772)		PF(n = 340)		TP(n = 242)		P
Adverse event (toxicity grade)	0–2(%)	3–4(%)	0–2(%)	3–4(%)	0–2(%)	3–4(%)	P
Leukocytopenia	579(75.0)	193(25.0)	324(95.3)	16(4.7)	199(82.2)	43(17.1)	< 0.001^a
Neutropenia	443(57.4)	329(42.6)	296(87.1)	44(12.9)	156(64.5)	86(35.5)	< 0.001^a
Anemia	763(98.8)	9(1.2)	339(99.7)	1(0.3)	240(99.2)	2(0.8)	0.441 ^b
Thrombocytopenia	765(99.1)	7(0.9)	338(99.4)	2(0.6)	239(98.8)	3(1.2)	0.672^b
ALT increase	763(99.0)	8(1.0)	337(99.1)	3(0.9)	239(98.8)	3(1.2)	0.871 ^b
AST increase	771(99.9)	1(0.1)	339(99.7)	1(0.3)	241(99.6)	1(0.4)	0.395^b
Creatinine increase	771(99.9)	1(0.1)	339(99.7)	1(0.3)	242(100)	0(0.0)	0.675^b
BUN increase	771(99.9)	1(0.1)	340(100)	0(0.0)	240(99.2)	2(0.8)	0.134^b

Abbreviations: IC Induction chemotherapy, TPF Taxanes plus cisplatin with fluorouracil, PF Cisplatin with fluorouracil, TP Taxanes with cisplatin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, BUN blood urea nitrogen
^aP values were calculated by Chi-square test. ^bP value calculated with Fisher’s exact test

ISSN: 1471-2407