Table 5 Multivariate analysis (Cox proportional hazards model)

TMIT

0.022*

–

Type III & IV vs. Type I

1.831

1.122–2.989

0.015*

–

–

–

Type II vs. Type I

1.955

1.208–3.164

0.006*

–

–

–

CD8

Low vs. high expression

–

–

–

1.406

1.021–1.936

0.037*

PD-L1

Positive vs. Negative expression

–

–

–

1.239

0.903–1.700

0.184

pT category

<  0.001*

<  0.001*

pT3 vs. pT1–2

2.029

1.209–3.406

0.007*

2.072

1.230–3.488

0.006*

pT4 vs. pT1–2

3.716

2.027–6.813

<  0.001*

3.838

2.092–7.039

<  0.001*

Lymph node

metastasis

Presence vs. Absence

1.899

1.408–2.561

<  0.001*

1.955

1.450–2.636

<  0.001*

Deficient mismatch repair

Absence vs. Presence

1.780

0.871–3.640

0.114

1.827

0.894–3.732

0.098

Age

More than 67 vs. less than 67 years

1.687

1.224–2.326

0.001*

1.662

1.207–2.290

0.002*

Chemotherapy or Radiotherapy

Only resection vs. Resection with chemo- or radiotherapy

2.039

1.491–2.789

<  0.001*

2.086

1.526–2.852

<  0.001*