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Table 3 Univariate and multivariate analyses

From: Development of a disease-specific graded prognostic assessment index for the management of sarcoma patients with brain metastases (Sarcoma-GPA)

Variable

UVA

MVA

p-value

HR

95% CI

p-value

HR

95% CI

Lower

Upper

Lower

Upper

Age (reference: > 55)

 Age [45–55]

.209

.765

.503

1.162

.099

.685

.436

1.074

 Age < 45

.003

.646

.483

.863

.802

.957

.677

1.352

Gender

.620

.934

.714

1.222

    

Sarcoma_type (bone vs soft tissue)

.701

.936

.667

1.312

    

Histology (reference: H1)

 Histology: H2

.016

.557

.346

.896

.006

.493

.297

.819

 Histology: H3

.000

.381

.231

.627

.000

.334

.192

.581

 Histology: H4

.000

.129

.063

.263

.000

.159

.072

.349

Grade (reference: 3)

 Grade = 2

.157

.756

.513

1.114

    

 Grade = 1

.174

.561

.244

1.291

    

Extracranial metastases (no, yes)

.679

.907

.571

1.441

    

Extracranial metastases: Lung (no, yes)

.621

1.079

.798

1.458

    

Extracranial metastases: Liver (no, yes)

.521

.881

.598

1.297

    

Extracranial metastases: Bone (no, yes)

.563

1.099

.798

1.513

    

Extracranial metastases: other (no, yes)

.291

.853

.636

1.145

    

Number of CNS metastases (reference: > 4)

 Number of CNS metastases (2–4)

.007

.590

.402

.866

.092

.699

.462

1.060

 Number of CNS metastases (1)

.000

.453

.314

.654

.022

.620

.412

.933

ECOG PS (reference: 3 or 4)

 ECOG PS = 2

.001

.523

.359

.761

.000

.468

.314

.696

 PS (0 or 1)

.000

.274

.195

.384

.000

.305

.211

.441

Localisation (reference: supra-tentorial)

 Localisation: infra-tentorial

.317

.763

.450

1.295

    

 Localisation: supra-tentorial & infra-tentorial

.887

1.057

.490

2.282

    

Localisation: meningeal

.120

1.555

.892

2.712

    

Localisation: parenchymal & meningeal

.504

.801

.417

1.537

    

TTBM (reference: < 12 months)

 TTBM (12–24 months)

.536

1.120

.782

1.604

.934

1.017

.686

1.507

 TTBM (24–60 months)

.746

.944

.667

1.336

.461

.869

.598

1.263

 TTBM > 60 months

.000

.453

.299

.686

.006

.526

.332

.834

  1. CI confidence interval, ECOG Eastern Cooperative Oncology Group, H1-H4 histology groups (see text for description), HR hazard ratio, MVA multivariate analysis, No number, PS performance status, TTBM time to brain metastasis (in months), UVA univariate analysis
  2. Entries in bold represent statistically significant values
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BMC Cancer

ISSN: 1471-2407

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