Variable | UVA | MVA | ||||||
---|---|---|---|---|---|---|---|---|
p-value | HR | 95% CI | p-value | HR | 95% CI | |||
Lower | Upper | Lower | Upper | |||||
Age (reference: > 55) | ||||||||
Age [45–55] | .209 | .765 | .503 | 1.162 | .099 | .685 | .436 | 1.074 |
Age < 45 | .003 | .646 | .483 | .863 | .802 | .957 | .677 | 1.352 |
Gender | .620 | .934 | .714 | 1.222 | ||||
Sarcoma_type (bone vs soft tissue) | .701 | .936 | .667 | 1.312 | ||||
Histology (reference: H1) | ||||||||
Histology: H2 | .016 | .557 | .346 | .896 | .006 | .493 | .297 | .819 |
Histology: H3 | .000 | .381 | .231 | .627 | .000 | .334 | .192 | .581 |
Histology: H4 | .000 | .129 | .063 | .263 | .000 | .159 | .072 | .349 |
Grade (reference: 3) | ||||||||
Grade = 2 | .157 | .756 | .513 | 1.114 | ||||
Grade = 1 | .174 | .561 | .244 | 1.291 | ||||
Extracranial metastases (no, yes) | .679 | .907 | .571 | 1.441 | ||||
Extracranial metastases: Lung (no, yes) | .621 | 1.079 | .798 | 1.458 | ||||
Extracranial metastases: Liver (no, yes) | .521 | .881 | .598 | 1.297 | ||||
Extracranial metastases: Bone (no, yes) | .563 | 1.099 | .798 | 1.513 | ||||
Extracranial metastases: other (no, yes) | .291 | .853 | .636 | 1.145 | ||||
Number of CNS metastases (reference: > 4) | ||||||||
Number of CNS metastases (2–4) | .007 | .590 | .402 | .866 | .092 | .699 | .462 | 1.060 |
Number of CNS metastases (1) | .000 | .453 | .314 | .654 | .022 | .620 | .412 | .933 |
ECOG PS (reference: 3 or 4) | ||||||||
ECOG PS = 2 | .001 | .523 | .359 | .761 | .000 | .468 | .314 | .696 |
PS (0 or 1) | .000 | .274 | .195 | .384 | .000 | .305 | .211 | .441 |
Localisation (reference: supra-tentorial) | ||||||||
Localisation: infra-tentorial | .317 | .763 | .450 | 1.295 | ||||
Localisation: supra-tentorial & infra-tentorial | .887 | 1.057 | .490 | 2.282 | ||||
Localisation: meningeal | .120 | 1.555 | .892 | 2.712 | ||||
Localisation: parenchymal & meningeal | .504 | .801 | .417 | 1.537 | ||||
TTBM (reference: < 12 months) | ||||||||
TTBM (12–24 months) | .536 | 1.120 | .782 | 1.604 | .934 | 1.017 | .686 | 1.507 |
TTBM (24–60 months) | .746 | .944 | .667 | 1.336 | .461 | .869 | .598 | 1.263 |
TTBM > 60 months | .000 | .453 | .299 | .686 | .006 | .526 | .332 | .834 |