Fig. 1

Volcano plot, observed co-expressed genes, protein-protein interaction (PPI) network, and biological process analysis of DEGs. The DEGs were screened with criteria of p < 0.01 and absolute value logFC (fold change) > 1; the red dots represent downregulated genes and the blue dots represent unchanged genes (a). The observed co-expressed genes of DEGs in Homo sapiens are shown in triangular matrices; the intensity of color indicates the level of confidence that two proteins are functionally associated (b). The PPI network of the DEGs; the network nodes represent proteins and the edges represent the protein-protein associations (c). Biological process analysis of the DEGs was performed and visualized using BiNGO; the color depth of the nodes refers to the corrected p values of the ontologies (d)