Establishment and validation of a nomogram with intratumoral heterogeneity derived from 18F-FDG PET/CT for predicting individual conditional risk of 5-year recurrence before initial treatment of nasopharyngeal carcinoma

Table 3 Significant predictors of PFS in multivariate analysis in the training cohort

Parameters	Multivariate Cox analysis					Cox model bootstrap validation (1000 samples)
Parameters	HR [95% CI]	P	C-index	Standardized regression coefficient	SE	HR [95% CI]	P	C-index
M stage	6.44 [1.72–24.08]	0.006	0.74	1.86	0.67	6.35 [1.72–23.43]	0.006	0.72
TLG-T-70%	1.02 [1.01–1.04]	0.002		0.02	0.01	1.02 [1.01–1.04]	0.004
HI-N	3.23 [1.22–8.54]	0.018		1.17	0.50	3.70 [1.59–8.61]	0.025

Abbreviations: PFS Progression-free survival, HR Hazard ratio, CI Confidence interval, SE Standard error, TLG-T Total lesion glucose of tumor, HI-N Heterogeneity index of maximal neck lymph node

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