Fig. 3

GO, KEGG and pathway enrichment analyses for circRNAs. The biological process, cellular component and molecular function that circRNAs were implicated in was revealed by GO enrichment analysis (a, c). In GO category, dot, triangle and square was used to symbolize BP, CC and MF respectively; the size of the symbols presented the gene counts; the gradation of color stood for the value of minus log10 adjusted P value. The cellular signaling pathways that circRNAs were implicated in were assessed by KEGG enrichment analysis (b) and pathway enrichment analysis (d). In KEGG by located genes, the size of the dot presented the gene counts; the gradation of color stood for the value of minus log10 P value. In pathway enrichment analysis by target miRNAs, category, dot, triangle and square was used to symbolize DO, HPO and KEGG respectively; the size of the symbols presented the gene counts; the gradation of color stood for the value of minus log10 P value. BP, biological process; CC, cellular component; MF, molecular function; DO, disease ontology; HPO, human phenotype ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; circRNAs, circular RNAs