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Table 2 Trends of glioblastoma incidence in the elderly population: The SEER 18 registry database, 2000–201

From: Recent incidence trend of elderly patients with glioblastoma in the United States, 2000–2017

Characteristics Period APC (95% CI) P
Overall 2000–2017 0.3 (−0.1, 0.7) 0.111
Gender
 Male 2000–2017 0.2 (− 0.2, 0.6) 0.272
 Female 2000–2017 0.2 (− 0.4, 0.8) 0.402
Race
 Non-Hispanic White 2000–2017 0.6 (0.2, 1.1) 0.013c
 Non-Hispanic Black 2000–2017 0.2 (−0.8, 1.3) 0.648
 Hispanic 2000–2017 0.0 (−0.9, 0.8) 0.923
 API 2001–2017 0.7 (−0.6, 1.9) 0.266
Age at diagnosis, years
 65–69 2000–2017 0.3 (−0.2, 0.8) 0.219
 70–74 2000–2017 0.0 (−0.6, 0.6) 0.976
 75–79 2000–2017 0.3 (−0.5, 1.0) 0.482
 80–84 2000–2017 0.8 (−0.1, 1.7) 0.092
 ≥85 2000–2017 0.6 (−0.3, 1.4) 0.186
Histologic type
 Glioblastoma, NOS 2000–2017 0.3 (−0.1, 0.7) 0.107
 Giant cell glioblastoma 2000–2017 −2.3 (−6.1, 1.7) 0.239
 Gliosarcoma 2000–2017 1.2 (−1.0, 3.4) 0.264
Tumor location
 Supratentorial 2000–2017 0.7 (0.2, 1.3) 0.016c
 Supratentoriala 2000–2004 5.1 (0.3, 10.2) 0.039c
 Supratentoriala 2004–2017 0.0 (−0.6, 0.7) 0.899
  Frontal 2000–2017 1.7 (1.0, 2.5) < 0.001c
  Temporal 2000–2017 0.9 (0.3, 1.6) 0.010c
  Parietal 2000–2017 −0.7 (−1.3, 0.0) 0.060
  Occipital 2000–2017 −0.4 (−1.7, 0.9) 0.494
 Infratentorial 2000–2017 −0.4 (−3.3, 2.5) 0.750
 Overlapping/NOS 2000–2017 −0.9 (−1.6, − 0.2) 0.012c
Tumor size, cmb
 < 4 2004–2015 2.5 (1.4, 3.6) < 0.001c
 ≥4 2004–2015 0.8 (0.0, 1.6) 0.057
 Unknown 2004–2015 −4.9 (−6.6, −3.3) < 0.001c
  1. Abbreviations: APC annual percentage change, CI confidence interval, API Asian/Pacific Islander, NOS not otherwise specified
  2. a A statistically significant change in the APC was observed after join-point analysis
  3. b Data are only documented between 2004 and 2015
  4. c Statistically significant