Comparison of long-term outcomes between Lynch sydrome and sporadic colorectal cancer: a propensity score matching analysis

Table 3 Factors associated with overall survival in the patients of LS and SCRC group (univariate and multivariate analysis)

Variable	N. patients	N. events^a	Univariate analysis		Multivariate analysis
Total	141	28	χ²	p value	Risk ratio (95% CI)	p value
Sex			4.745	0.028	1.360 (0.525–0.770)	0.527
Male	80	24
Female	61	4
Age			0.022	0.883
< 50	103	21
≥50	38	7
CEA			0.482	0.488
< 5.2	118	21
≥5.2	23	7
Etiology			4.745	0.029	0.106(0.025–0.446)	0.002
Lynch syndrome	47	4
Sporadic CRC	94	24
Location			3.235	0.357
Right colon	58	8
Left colon	61	14
Rectal	16	3
Multiple	6	3
Pathological classification			11.122	0.004	1.504(0.770–2.937)	0.233
Adenocarcinoma	105	21
Partial mucinous	16	0
Mucinous adenocarcinoma	20	7
Differentiation grade			2.611	0.271
Well	2	0
Moderately	84	15
Poorly	55	13
Cancerous node			13.123	< 0.001	3.285(0.860–12.546)	0.082
Occurrence	9	5
Absence	132	23
Vascular invasion			10.163	0.001	3.404(0.915–12.662)	0.068
Occurrence	112	17
Absence	29	11
Perineural invasion			41.204	< 0.001	0.707(0.247–2.028)	0.519
Occurrence	21	13
Absence	120	15
TNM stage			57.546	< 0.001	2.968(1.478–5.964)	0.002
I	40	2
II	47	4
III	46	16
IV	8	6
KRAS			0.225	0.636
Wild type	71	9
Variant type	70	19
NRAS			0.011	0.916
Wild type	136	27
Variant type	5	1
Recurrence of primary CRC			106.81	< 0.001	48.917(9.866–242.539)	< 0.001
Occurrence	35	25
Absence	106	3

CEA Carcinoembryonic antigen, LS Lynch syndrome, SCRC Sporadic colorectal cancer, N. Number, CI Confidence interval, CRC Colorectal cancer
^aEvents refers to death

ISSN: 1471-2407