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Table 3 Factors associated with overall survival in the patients of LS and SCRC group (univariate and multivariate analysis)

From: Comparison of long-term outcomes between Lynch sydrome and sporadic colorectal cancer: a propensity score matching analysis

Variable N. patients N. eventsa Univariate analysis Multivariate analysis
Total 141 28 χ2 p value Risk ratio (95% CI) p value
Sex    4.745 0.028 1.360 (0.525–0.770) 0.527
 Male 80 24     
 Female 61 4     
Age    0.022 0.883   
 < 50 103 21     
 ≥50 38 7     
CEA    0.482 0.488   
 < 5.2 118 21     
 ≥5.2 23 7     
Etiology    4.745 0.029 0.106(0.025–0.446) 0.002
 Lynch syndrome 47 4     
 Sporadic CRC 94 24     
Location    3.235 0.357   
 Right colon 58 8     
 Left colon 61 14     
 Rectal 16 3     
 Multiple 6 3     
Pathological classification    11.122 0.004 1.504(0.770–2.937) 0.233
 Adenocarcinoma 105 21     
 Partial mucinous 16 0     
 Mucinous adenocarcinoma 20 7     
Differentiation grade    2.611 0.271   
 Well 2 0     
 Moderately 84 15     
 Poorly 55 13     
Cancerous node    13.123 < 0.001 3.285(0.860–12.546) 0.082
 Occurrence 9 5     
 Absence 132 23     
Vascular invasion    10.163 0.001 3.404(0.915–12.662) 0.068
 Occurrence 112 17     
 Absence 29 11     
Perineural invasion    41.204 < 0.001 0.707(0.247–2.028) 0.519
 Occurrence 21 13     
 Absence 120 15     
TNM stage    57.546 < 0.001 2.968(1.478–5.964) 0.002
 I 40 2     
 II 47 4     
 III 46 16     
 IV 8 6     
KRAS    0.225 0.636   
 Wild type 71 9     
 Variant type 70 19     
NRAS    0.011 0.916   
 Wild type 136 27     
 Variant type 5 1     
Recurrence of primary CRC    106.81 < 0.001 48.917(9.866–242.539) < 0.001
 Occurrence 35 25     
 Absence 106 3     
  1. CEA Carcinoembryonic antigen, LS Lynch syndrome, SCRC Sporadic colorectal cancer, N. Number, CI Confidence interval, CRC Colorectal cancer
  2. aEvents refers to death
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BMC Cancer

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