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Table 3 Summary odds ratio (OR) or relative risk (RR) Estimates [95% confidence intervals (CIs)] for observational studies conducted on The association between ATM variants and risk of breast cancer

From: The association between ATM variants and risk of breast cancer: a systematic review and meta-analysis

Subgroup

Number OR in primary studies

Summery effect size (95% CI)

Between studies

Between subgroups

I2

P heterogeneity

z

Q

P heterogeneity

Adjusted Case Control studies

 Heterozygosity variants

  Hetro

13

1.98 (1.22–3.19)

80%

0.0001

2.78

5.03

0.0001

  Hemo

4

1.63 (1.20–2.22)

0.0%

0.929

2.12

  

  Hetro/Hemo

7

1.22 (1.01–1.46)

0.0%

0.433

3.14

  

 Continent

  Asia

2

4.21 (0.78–22.88)

89.5%

0.0001

1.67

4.03

0.0001

  America

3

1.55 (1.19–2.01)

60.4%

0.001

3.22

  

  European

2

1.24 (0.94–1.64)

18.5%

0.297

1.49

  

 Type

  c.7271 T > G

2

8.94 (4.28–18.67)

0.0%

0.789

5.83

  

  D1853V

2

0.43 (0.09–2.07)

78.6%

0.031

1.05

  

  S707P

3

1.17 (0.73–1.87)

49.2%

0.140

0.66

4.03

0.0001

  F858L

2

1.43 (1.02–2.00)

0.0%

0.943

2.10

  

  IVS38–8 T > C, c.5557G > A

2

1.90 (0.80–4.48)

48.9%

0.162

1.46

  

  IVS38–8 T > C

2

3.04 (1.48–6.25)

0.0%

0.963

3.04

  

  IVS24-9delT

2

1.70 (1.13–2.57)

0.0%

0.922

2.54

  

  5557G > A

3

1.33 (0.89–1.99)

54.7%

0.110

1.39

  

  IVS24-9delT, IVS38–8 T > C,

2

1.90 (0.80–4.48)

48.9%

0.162

1.46

  

  5557G > A

2

1.90 (0.80–4.48)

48.9%

0.162

1.46

  

 IVS24-9delT, IVS38–8 T > C

       

Unadjusted Case Control studies

 Heterozygosity variants

  Hetro

28

1.31 (1.05–1.64)

76.3%

0.0001

2.35

3.89

0.001

  Hetro/Hemo

3

3.43 (0.99–11.84)

90.9%

0.0001

1.95

  

 Continent

  Asia

3

5.37 (1.66–17.48)

86.5%

0.0001

2.79

  

  America

2

1.58 (1.07–2.33)

67.8%

0.0001

2.32

3.89

0.0001

  European

4

1.08 (0.85–1.38)

74.8%

0.0001

0.63

  

 Type

  c.1066–6 T > G

8

1.69 (0.91–3.14)

78.1%

0.0001

1.67

  

  Ser49Cys

3

9.24 (4.78–17.87)

0.0%

0.468

6.61

  

  7271 T > G (V2424G)

2

27.97 (5.01–35.07)

62%

0.105

3.80

3.89

0.0001

  IVS38–8 T > C

6

1.22 (0.98–1.51)

0.0%

0.874

1.78

  

  D1853N

6

1.22 (0.98–1.51)

58.9%

0.032

0.67

  
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