Fig. 1

Osteogenic differentiation of mesenchymal stromal cells (MSCs) in the presence of R-2HG. a. MSCs were grown in osteo-inductive medium for 14 days in the absence or presence of R-2HG (1, 1.5 mM). Mineralization was assessed by Alizarin red staining. Scale bar = 100 μM (b): Quantitative results of expression levels of differentiation-related genes. * P < 0.05 vs the group of MSC in absence of R-2HG. ** P < 0.01 vs the group of MSC in absence of R-2HG