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Table 3 HPV genotypes in single, multiple, and mixed-HPV infections in cervix without SIL, with SIL and CC

From: TOP2A/MCM2, p16INK4a, and cyclin E1 expression in liquid-based cytology: a biomarkers panel for progression risk of cervical premalignant lesions

  O-Risk NSIL LSIL HSIL CC
  n = 239 % n = 901 % n = 54 % n = 291 %
HPV negative   74 30.9 1 0.1 0 0.0 5 1.7
Single HPV infection
 16 HR 40 16.7 119 13.2 7 13.0 123 42.3
 18 HR 4 1.7 13 1.4 3 5.6 23 7.9
 51 HR 6 2.5 19 2.1 1 1.8 0 0.0
 52 HR 2 0.8 19 2.1 0 0.0 4 1.4
 45 HR 1 0.4 7 0.8 1 1.8 13 4.5
 66 PHR 7 2.9 41 4.4 2 3.7 0 0.0
 53 PHR 9 3.8 23 2.5 1 1.8 0 0.0
 68 PHR 0 0.0 10 1.1 0 0.0 1 0.3
 26 PHR 0 0.0 2 0.2 0 0.0 1 0.3
 83 PHR 0 0.0 3 0.3 0 0.0 0 0.0
 6 LR 15 6.3 62 6.9 0 0.0 1 0.3
 70 LR 1 0.4 8 0.9 0 0.0 0 0.0
 11 LR 0 0.0 7 0.8 0 0.0 1 0.3
 54 LR 0 0.0 8 0.9 0 0.0 0 0.0
 44 LR 2 0.8 5 0.5 0 0.0 0 0.0
 74 UR 2 0.8 10 1.1 0 0.0 0 0.0
 62 UR 0 0.0 4 0.4 0 0.0 0 0.0
 69 UR 0 0.0 0 0.0 0 0.0 4 1.4
 89 UR 0 0.0 2 0.2 0 0.0 0 0.0
 67 UR 0 0.0 0 0.0 0 0.0 1 0.3
Multiple HPV infection
 16 and 52 HR 0 0.0 7 0.8 1 1.8 6 2.0
 31 and 33 HR 1 0.4 6 0.7 4 7.4 3 1.0
 16 and 18 HR 0 0.0 8 0.9 1 1.8 4 1.4
 16 and 56 HR 1 0.4 4 0.4 1 1.8 0 0.0
 16 and 39 HR 0 0.0 2 0.2 0 0.0 2 0.7
 53 and 66 PHR 1 0.4 6 0.7 0 0.0 0 0.0
 58 and 68 PHR 0 0.0 2 0.2 0 0.0 0 0.0
 66 and 53 PHR 0 0.0 2 0.2 0 0.0 0 0.0
 66 and 68 PHR 0 0.0 1 0.1 0 0.0 0 0.0
 11 and 54 LR 1 0.4 1 0.1 0 0.0 0 0.0
 6 and 11 LR 0 0.0 0 0.0 1 1.8 0 0.0
 6 and 54 LR 0 0.0 1 0.1 0 0.0 0 0.0
 6 and 7 LR 0 0.0 1 0.1 0 0.0 0 0.0
 6 and 70 LR 0 0.0 1 0.1 0 0.0 0 0.0
 69 and 71 UR 1 0.4 3 0.3 1 1.8 0 0.0
Mixed HPV infection
 16 and 6 HR, LR 4 1.7 20 2.2 1 1.8 3 1.0
 53 and 6 PHR, LR 0 0.0 8 0.9 0 0.0 0 0.0
 16 and 53 HR, PHR 1 0.4 6 0.7 0 0.0 0 0.0
 66 and 6 PHR, LR 0 0.0 6 0.7 0 0.0 1 0.3
 39 and 6 HR, LR 0 0.0 4 0.4 0 0.0 2 0.7
 68 and 6 PHR, LR 1 0.4 5 0.5 0 0.0 0 0.0
 16 and 68 HR, PHR 0 0.0 5 0.5 0 0.0 0 0.0
 16 and 66 HR, PHR 0 0.0 4 0.4 0 0.0 0 0.0
 18 and 6 HR, LR 0 0.0 3 0.3 0 0.0 1 0.3
  1. O-Risk Oncogenic risk, NSIL Non-squamous intraepithelial lesions, LSIL Low-grade squamous intraepithelial lesions, HSIL High-grade squamous intraepithelial lesions, CC Cervical cancer, HR High risk, PHR Probably high risk, LR Low risk, UR Indeterminate risk. Single HPV Infection with one genotype (shown are the five most prevalent genotypes by risk group), Multiple HPV Infection with two genotypes of the same risk group (shown are the most prevalent genotypes by risk group), Mixed HPV Infection with genotypes of different risk groups (shown are the most prevalent combinations)