TOP2A/MCM2, p16INK4a, and cyclin E1 expression in liquid-based cytology: a biomarkers panel for progression risk of cervical premalignant lesions

Table 3 HPV genotypes in single, multiple, and mixed-HPV infections in cervix without SIL, with SIL and CC

	O-Risk	NSIL		LSIL		HSIL		CC
		n = 239	%	n = 901	%	n = 54	%	n = 291	%
HPV negative		74	30.9	1	0.1	0	0.0	5	1.7
Single HPV infection
16	HR	40	16.7	119	13.2	7	13.0	123	42.3
18	HR	4	1.7	13	1.4	3	5.6	23	7.9
51	HR	6	2.5	19	2.1	1	1.8	0	0.0
52	HR	2	0.8	19	2.1	0	0.0	4	1.4
45	HR	1	0.4	7	0.8	1	1.8	13	4.5
66	PHR	7	2.9	41	4.4	2	3.7	0	0.0
53	PHR	9	3.8	23	2.5	1	1.8	0	0.0
68	PHR	0	0.0	10	1.1	0	0.0	1	0.3
26	PHR	0	0.0	2	0.2	0	0.0	1	0.3
83	PHR	0	0.0	3	0.3	0	0.0	0	0.0
6	LR	15	6.3	62	6.9	0	0.0	1	0.3
70	LR	1	0.4	8	0.9	0	0.0	0	0.0
11	LR	0	0.0	7	0.8	0	0.0	1	0.3
54	LR	0	0.0	8	0.9	0	0.0	0	0.0
44	LR	2	0.8	5	0.5	0	0.0	0	0.0
74	UR	2	0.8	10	1.1	0	0.0	0	0.0
62	UR	0	0.0	4	0.4	0	0.0	0	0.0
69	UR	0	0.0	0	0.0	0	0.0	4	1.4
89	UR	0	0.0	2	0.2	0	0.0	0	0.0
67	UR	0	0.0	0	0.0	0	0.0	1	0.3
Multiple HPV infection
16 and 52	HR	0	0.0	7	0.8	1	1.8	6	2.0
31 and 33	HR	1	0.4	6	0.7	4	7.4	3	1.0
16 and 18	HR	0	0.0	8	0.9	1	1.8	4	1.4
16 and 56	HR	1	0.4	4	0.4	1	1.8	0	0.0
16 and 39	HR	0	0.0	2	0.2	0	0.0	2	0.7
53 and 66	PHR	1	0.4	6	0.7	0	0.0	0	0.0
58 and 68	PHR	0	0.0	2	0.2	0	0.0	0	0.0
66 and 53	PHR	0	0.0	2	0.2	0	0.0	0	0.0
66 and 68	PHR	0	0.0	1	0.1	0	0.0	0	0.0
11 and 54	LR	1	0.4	1	0.1	0	0.0	0	0.0
6 and 11	LR	0	0.0	0	0.0	1	1.8	0	0.0
6 and 54	LR	0	0.0	1	0.1	0	0.0	0	0.0
6 and 7	LR	0	0.0	1	0.1	0	0.0	0	0.0
6 and 70	LR	0	0.0	1	0.1	0	0.0	0	0.0
69 and 71	UR	1	0.4	3	0.3	1	1.8	0	0.0
Mixed HPV infection
16 and 6	HR, LR	4	1.7	20	2.2	1	1.8	3	1.0
53 and 6	PHR, LR	0	0.0	8	0.9	0	0.0	0	0.0
16 and 53	HR, PHR	1	0.4	6	0.7	0	0.0	0	0.0
66 and 6	PHR, LR	0	0.0	6	0.7	0	0.0	1	0.3
39 and 6	HR, LR	0	0.0	4	0.4	0	0.0	2	0.7
68 and 6	PHR, LR	1	0.4	5	0.5	0	0.0	0	0.0
16 and 68	HR, PHR	0	0.0	5	0.5	0	0.0	0	0.0
16 and 66	HR, PHR	0	0.0	4	0.4	0	0.0	0	0.0
18 and 6	HR, LR	0	0.0	3	0.3	0	0.0	1	0.3

O-Risk Oncogenic risk, NSIL Non-squamous intraepithelial lesions, LSIL Low-grade squamous intraepithelial lesions, HSIL High-grade squamous intraepithelial lesions, CC Cervical cancer, HR High risk, PHR Probably high risk, LR Low risk, UR Indeterminate risk. Single HPV Infection with one genotype (shown are the five most prevalent genotypes by risk group), Multiple HPV Infection with two genotypes of the same risk group (shown are the most prevalent genotypes by risk group), Mixed HPV Infection with genotypes of different risk groups (shown are the most prevalent combinations)

ISSN: 1471-2407