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Table 2 Correlation analysis between NCOA4 and markers of immune cells in TIMER and GEPIA

From: Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma

Cell type Gene marker None Purity Tum our Normal
Cor P Cor P R P R P
B cell CD19 −0.068 0.119 −0.069 0.139 −0.072 0.1 −0.16 0.18
CD20(KRT20) −0.023 0.593 −0.014 0.771 0.073 0.096 −0.087 0.47
CD38 0.304 *** 0.299 *** 0.13 ** 0.081 0.5
CD8+ T cell CD8A 0.112 ** 0.089 0.0567 0.11 * −0.15 0.22
CD8B 0.074 0.0897 0.046 0.329 0.09 * −0.23 0.053
Tfh BCL6 0.076 0.0807 0.066 0.159 0.17 *** 0.13 0.27
ICOS Cor *** 0.203 *** 0.19 *** −0.059 0.62
CXCR5 −0.034 0.431 −0.022 0.634 −0.52 *** −0.29 *
Th1 T-bet (TBX21) 0.061 0. 0.04 0.393 0.08 0.067 −0.14 0.26
STAT4 0.065 0.136 0.052 0.269 0.1 * −0.016 0.89
IL12RB2 0.241 *** 0.216 *** 0.25 *** 0.093 0.44
WSX1(IL27RA) −0.069 0.113 −0.1 * −0.034 0.43 0.072 0.55
STAT1 0.484 *** 0.476 *** 0.42 *** 0.26 *
IFN-γ (IFNG) 0.027 0.531 0.005 0.917 0.043 0.33 −0.16 0.17
TNF-α (TNF) 0.146 *** 0.154 *** 0.15 *** 0.17 0.15
Th2 GATA3 −0.072 0.955 −0.042 0.364 −0.085 0.053 0.3 **
CCR3 0.203 *** 0.205 *** 0.092 * −0.033 0.78
STAT6 0.377 *** 0.367 *** 0.3 *** 0.22 0.069
STAT5A 0.355 *** 0.344 *** 0.38 *** 0.15 0.2
Th9 TGFBR2 0.62 *** 0.593 *** 0.59 *** −0.089 0.46
IRF4 0.151 *** 0.151 ** 0.04 0.36 −0.12 0.3
PU.1(SPI1) 0.063 0.144 0.047 0.318 0.083 0.058 −0.082 0.49
Th17 STAT3 0.599 *** 0.592 *** 0.6 *** 0.33 **
IL-21R 0.151 *** 0.142 ** 0.11 * −0.19 0.11
IL-23R 0.2 *** 0.21 *** 0.13 ** 0.014 0.91
IL-17A −0.052 0.233 −0.026 0.581 −0.013 0.78 0.071 0.55
Th22 CCR10 −0.18 *** −0.185 *** −0.13 ** −0.18 0.14
AHR 0.537 *** 0.534 *** 0.58 *** 0.23 0.05
Treg FOXP3 −0.082 0.0572 −0.096 * −0.11 * −0.05 0.68
CD25(IL2RA) 0.312 *** 0.293 *** 0.1 * −0.025 0.83
CCR8 0.211 *** 0.207 *** 0.17 *** −0.099 0.41
T cell exhaustion PD-1 (PDCD1) −0.073 0.0939 −0.092 * −0.011 0.8 −0.3 *
CTLA4 −0.002 0.962 −0.005 0.911 0.017 0.69 −0.038 0.75
LAG3 −0.074 0.0882 −0.088 0.0578 −0.022 0.61 0.14 0.23
TIM-3 (HAVCR2) 0.366 *** 0.337 *** 0.31 *** −0.055 0.65
Macrophage CD68 0.335 *** 0.293 *** 0.4 *** −0.049 0.68
CD11b (ITGAM) 0.391 *** 0.383 *** 0.15 *** 0.018 0.88
M1 INOS (NOS2) 0.349 *** 0.324 *** 0.13 ** 0.0074 0.95
IRF5 0.134 ** 0.139 ** 0.14 ** 0.26 *
COX2(PTGS2) 0.114 ** 0.143 ** −0.019 0.66 0.26 *
M2 CD16 0.531 *** 0.514 *** 0.26 *** −0.029 0.81
ARG1 0.069 0.111 0.046 0.32 −0.019 0.67 −0.21 0.079
MRC1 0.583 *** 0.567 *** 0.51 *** 0.13 0.28
MS4A4A 0.461 0.0528 0.453 *** 0.45 *** 0.024 0.84
TAM CCL2 0.084 *** 0.114 * 0.075 *** 0.033 0.78
CD80 0.284 *** 0.3 *** 0.2 0.087 0.035 0.77
CD86 0.389 *** 0.392 *** 0.44 *** 0.065 0.59
CCR5 0.301 *** 0.3 *** 0.35 *** 0.16 0.17
Monocyte CD14 0.154 *** 0.132 ** 0.16 *** 0.032 0.79
CD16(FCGR3B) 0.355 *** 0.334 *** 0.2 *** 0.16 0.18
CD115 (CSF1R) 0.387 ** 0.376 *** 0.36 *** 0.039 0.74
Neutrophil CD66b (CEACAM8) 0.122 *** 0.12 * 0.078 *** 0.29 *
CD15(FUT4) 0.498 *** 0.491 *** 0.46 0.075 0.024 0.84
CD11b (ITGAM) 0.391 0.0673 0.383 *** 0.15 *** 0.018 0.88
Natural killer cell XCL1 −0.079 *** −0.086 0.0639 −0.039 *** −0.08 0.5
CD7 −0.226 0.107 −0.271 *** −0.067 0.37 −0.26 *
KIR3DL1 0.07 *** 0.041 0.382 0.085 0.13 −0.17 0.15
Dendritic cell CD1C(BDCA-1) 0.307 *** 0.29 *** 0.24 0.053 −0.026 0.83
CD141(THBD) 0.26 * 0.243 *** 0.29 *** −0.15 0.22
CD11c (ITGAX) 0.1 *** 0.115 * 0.034 *** −0.0063 0.96
  1. Tfh Follicular helper T cell, Th T helper cell, Treg Regulatory T cell, TAM Tumor-associated macrophage. None, Correlation without adjustment. Purity, Correlation adjusted by purity. Cor, R value of Spearman’s correlation. *P < 0.05; **P < 0.01; ***P < 0.001