Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma

Mou, Yanhua; Wu, Jinchun; Zhang, Yao; Abdihamid, Omar; Duan, Chaojun; Li, Bin

doi:10.1186/s12885-020-07726-z

Table 2 Correlation analysis between NCOA4 and markers of immune cells in TIMER and GEPIA

From: Low expression of ferritinophagy-related NCOA4 gene in relation to unfavorable outcome and defective immune cells infiltration in clear cell renal carcinoma

Cell type	Gene marker	None		Purity		Tum our		Normal
Cell type	Gene marker	Cor	P	Cor	P	R	P	R	P
B cell	CD19	−0.068	0.119	−0.069	0.139	−0.072	0.1	−0.16	0.18
	CD20(KRT20)	−0.023	0.593	−0.014	0.771	0.073	0.096	−0.087	0.47
	CD38	0.304	***	0.299	***	0.13	**	0.081	0.5
CD8+ T cell	CD8A	0.112	**	0.089	0.0567	0.11	*	−0.15	0.22
CD8+ T cell	CD8B	0.074	0.0897	0.046	0.329	0.09	*	−0.23	0.053
Tfh	BCL6	0.076	0.0807	0.066	0.159	0.17	***	0.13	0.27
	ICOS	Cor	***	0.203	***	0.19	***	−0.059	0.62
	CXCR5	−0.034	0.431	−0.022	0.634	−0.52	***	−0.29	*
Th1	T-bet (TBX21)	0.061	0.	0.04	0.393	0.08	0.067	−0.14	0.26
	STAT4	0.065	0.136	0.052	0.269	0.1	*	−0.016	0.89
	IL12RB2	0.241	***	0.216	***	0.25	***	0.093	0.44
	WSX1(IL27RA)	−0.069	0.113	−0.1	*	−0.034	0.43	0.072	0.55
	STAT1	0.484	***	0.476	***	0.42	***	0.26	*
	IFN-γ (IFNG)	0.027	0.531	0.005	0.917	0.043	0.33	−0.16	0.17
	TNF-α (TNF)	0.146	***	0.154	***	0.15	***	0.17	0.15
Th2	GATA3	−0.072	0.955	−0.042	0.364	−0.085	0.053	0.3	**
	CCR3	0.203	***	0.205	***	0.092	*	−0.033	0.78
	STAT6	0.377	***	0.367	***	0.3	***	0.22	0.069
	STAT5A	0.355	***	0.344	***	0.38	***	0.15	0.2
Th9	TGFBR2	0.62	***	0.593	***	0.59	***	−0.089	0.46
	IRF4	0.151	***	0.151	**	0.04	0.36	−0.12	0.3
	PU.1(SPI1)	0.063	0.144	0.047	0.318	0.083	0.058	−0.082	0.49
Th17	STAT3	0.599	***	0.592	***	0.6	***	0.33	**
	IL-21R	0.151	***	0.142	**	0.11	*	−0.19	0.11
	IL-23R	0.2	***	0.21	***	0.13	**	0.014	0.91
	IL-17A	−0.052	0.233	−0.026	0.581	−0.013	0.78	0.071	0.55
Th22	CCR10	−0.18	***	−0.185	***	−0.13	**	−0.18	0.14
Th22	AHR	0.537	***	0.534	***	0.58	***	0.23	0.05
Treg	FOXP3	−0.082	0.0572	−0.096	*	−0.11	*	−0.05	0.68
	CD25(IL2RA)	0.312	***	0.293	***	0.1	*	−0.025	0.83
	CCR8	0.211	***	0.207	***	0.17	***	−0.099	0.41
T cell exhaustion	PD-1 (PDCD1)	−0.073	0.0939	−0.092	*	−0.011	0.8	−0.3	*
	CTLA4	−0.002	0.962	−0.005	0.911	0.017	0.69	−0.038	0.75
	LAG3	−0.074	0.0882	−0.088	0.0578	−0.022	0.61	0.14	0.23
	TIM-3 (HAVCR2)	0.366	***	0.337	***	0.31	***	−0.055	0.65
Macrophage	CD68	0.335	***	0.293	***	0.4	***	−0.049	0.68
Macrophage	CD11b (ITGAM)	0.391	***	0.383	***	0.15	***	0.018	0.88
M1	INOS (NOS2)	0.349	***	0.324	***	0.13	**	0.0074	0.95
	IRF5	0.134	**	0.139	**	0.14	**	0.26	*
	COX2(PTGS2)	0.114	**	0.143	**	−0.019	0.66	0.26	*
M2	CD16	0.531	***	0.514	***	0.26	***	−0.029	0.81
	ARG1	0.069	0.111	0.046	0.32	−0.019	0.67	−0.21	0.079
	MRC1	0.583	***	0.567	***	0.51	***	0.13	0.28
	MS4A4A	0.461	0.0528	0.453	***	0.45	***	0.024	0.84
TAM	CCL2	0.084	***	0.114	*	0.075	***	0.033	0.78
	CD80	0.284	***	0.3	***	0.2	0.087	0.035	0.77
	CD86	0.389	***	0.392	***	0.44	***	0.065	0.59
	CCR5	0.301	***	0.3	***	0.35	***	0.16	0.17
Monocyte	CD14	0.154	***	0.132	**	0.16	***	0.032	0.79
	CD16(FCGR3B)	0.355	***	0.334	***	0.2	***	0.16	0.18
	CD115 (CSF1R)	0.387	**	0.376	***	0.36	***	0.039	0.74
Neutrophil	CD66b (CEACAM8)	0.122	***	0.12	*	0.078	***	0.29	*
	CD15(FUT4)	0.498	***	0.491	***	0.46	0.075	0.024	0.84
	CD11b (ITGAM)	0.391	0.0673	0.383	***	0.15	***	0.018	0.88
Natural killer cell	XCL1	−0.079	***	−0.086	0.0639	−0.039	***	−0.08	0.5
	CD7	−0.226	0.107	−0.271	***	−0.067	0.37	−0.26	*
	KIR3DL1	0.07	***	0.041	0.382	0.085	0.13	−0.17	0.15
Dendritic cell	CD1C(BDCA-1)	0.307	***	0.29	***	0.24	0.053	−0.026	0.83
	CD141(THBD)	0.26	*	0.243	***	0.29	***	−0.15	0.22
	CD11c (ITGAX)	0.1	***	0.115	*	0.034	***	−0.0063	0.96

Tfh Follicular helper T cell, Th T helper cell, Treg Regulatory T cell, TAM Tumor-associated macrophage. None, Correlation without adjustment. Purity, Correlation adjusted by purity. Cor, R value of Spearman’s correlation. *P < 0.05; **P < 0.01; ***P < 0.001

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