Fig. 4
F/B measured in tumor-stroma interface and bulk of primary tumor sections and relation to MFS. SHG F/B values were produced by a user-defined threshold for each individual image from the a, tumor bulk and b, tumor-stroma interface. Patients were split into four equal quartiles (Q1 = lowest F/B) based on F/B, and the percentage of each quartile surviving without metastasis then plotted versus time. Tick marks represent censoring events caused when a patient dies of a cause other than cancer or is lost to follow-up. Partial likelihood ratio tests for ln F/B: p = 0.05 (tumor bulk, n = 95) and p = 0.00008 (tumor-stroma interface, n = 92)