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Table 2 Micro-epidermis physiology is impaired following exposure to EGFRi and VEGFRi. Size of the epidermis and the expression of the protein junction desmoglein-1 (DSG1), involucrin (IVL) and filaggrin (FLG) was assessed by immunostaining and compared to untreated control. Drugs were classified by family and drug generation. Dose responses were determined by comparison of the variation of protein expression at 3, 10 and 30 nM for EGFRi and 3, 10, 30 and 100 nM for the VEGFRi. * p < 0.05 at 30 nM (EFGRi) or 100 nM (VEFGRi); ** p < 0.01 at 30 nM (EFGRi) or 100 nM (VEFGRi) and *** p < 0.001 at 30 nM (EFGRi) or 100 nM (VEFGRi)

From: EGFR inhibitors switch keratinocytes from a proliferative to a differentiative phenotype affecting epidermal development and barrier function