Fig. 2

Cell proliferation under cisplatin treatment. a Comparison of experimental data and simulation results for normalized cell viability of HeLa-C3 cells at different time points, b Contours plots of adduct concentration in the cells at the centre slice of simulated spheroid at different time points and (c) Comparison of experimental data and simulation results for spatial activity of cisplatin at different time points. Green spots in the experimental panel of (c) indicate live cells, cyan spots indicate dead cells due to apoptosis alone and red spots indicate dead cells from apoptosis triggered by cisplatin. Green spots in the simulation panel of (c) indicate live cells and red spots indicate dead cells. GraphPad Prism v6.01 was used to generate plot (a). Tecplot 360 2018 R1 was used to generate plots (b) and (c) simulations subplot