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Table 2 Tumoral regression among 89 resected patients

From: Phase II randomized trial of capecitabine with bevacizumab and external beam radiation therapy as preoperative treatment for patients with resectable locally advanced rectal adenocarcinoma: long term results

 

A (BVZ + CAPE + RT) (N = 44)

B (CAPE + RT) (N = 46)

Total (N = 90)

P Value Test

Pathologic response per tumoral regression (TRG)*

 TRG 1(Complete pathologic response)

N(%)

8 (18.18)

5 (10.87)

13 (14.44)

Fisher: 0.1458

 TRG 2

N(%)

8 (18.18)

15 (32.61)

23 (25.56)

 TRG 3

N(%)

14 (31.82)

19 (41.30)

33 (36.67)

 TRG 4

N(%)

12 (27.27)

6 (13.04)

18 (20.00)

 TRG 5(Disease progression)

N(%)

0 (0.00)

1 (2.17)

1 (1.11)

 ND

N(%)

1 (2.27)

0 (0.00)

1 (1.11)

 Missing

N(%)

1 (2.27)

0 (0.00)

1 (1.11)

ypT improvement

 Better

N(%)

26 (59.09)

18 (39.13)

44 (48.89)

Fisher: 0.0429

 Remained the same

N(%)

16 (36.36)

28 (60.87)

44 (48.89)

 Worse

N(%)

1 (2.27)

0 (0.00)

1 (1.11)

 Missing

N(%)

1 (2.27)

0 (0.00)

1 (1.11)

ypN improvement

 Better

N(%)

24 (54.55)

35 (76.09)

59 (65.56)

Fisher: 0.0865

 Remained the same

N(%)

15 (34.09)

8 (17.39)

23 (25.56)

 Worse

N(%)

4 (9.09)

2 (4.35)

6 (6.67)

 No evaluable*

N(%)

0 (0.00)

1 (2.17)

1 (1.11)

 Missing

N(%)

1 (2.27)

0 (0.00)

1 (1.11)

ypT and ypN improvement

 Improvement in both

N(%)

18 (40.91)

16 (34.78)

34 (37.78)

Fisher: 0.5612

 Improvement in one

N(%)

14 (31.82)

20 (43.48)

34 (37.78)

 No improvement

N(%)

11 (25.00)

9 (19.57)

20 (22.22)

 Non-evaluable*

N(%)

0 (0.00)

1 (2.17)

1 (1.11)

 Missing

N(%)

1 (2.27)

0 (0.00)

1 (1.11)

  1. * A patient was reported as NX