Predictive and prognostic role of tumour-infiltrating lymphocytes in breast cancer patients with different molecular subtypes: a meta-analysis

Gao, Zhao-hua; Li, Cun-xin; Liu, Ming; Jiang, Jia-yuan

doi:10.1186/s12885-020-07654-y

Table 1 Baseline characteristics of included studies

From: Predictive and prognostic role of tumour-infiltrating lymphocytes in breast cancer patients with different molecular subtypes: a meta-analysis

first author	year of publication	Country	Study design	Number (n)	Treatment type	sample time	TILs site	TIL evaluation method	curative resection	Endpoint measured	Follow up Median (range)(M)
Hwang, Hye Won [11]	2019	Korea	retrospective	308	NAC	pre-NAC/post-NAC	sTILs	HE	YES	pCR/DFS/BCSS	60.1
Ahn, S. G [12].	2018	Korea	retrospective	198	not NAC	resection tissue	sTILs	HE	NR	NO	NR
Yang, Xia [13]	2018	China	retrospective	143	NAC + H	pre-NAC/post-NAC	sTILs	HE	YES	pCR/DFS/OS	53 (12–102)
Herrero-Vicent, C [14].	2017	Spain	retrospective	164	NAC	pre-NAC/post-NAC	sTILs	HE	NR	pCR/DFS	78
Luen, S. J [15].	2019	Australia	retrospective	375	NAC	pre-NAC/post-NAC	sTILs	HE	NR	RFS/OS	72
Fujimoto, Yukie [16]	2019	Japan	retrospective	717	NAC/adjuvant	pre-NAC/post-NAC	iTILs+sTILs	HE	YES	DFS/OS	35.1 (1–100.6)
Adams, S [17].	2014	USA	RCT	481	adjuvant	resection tissue	iTILs+sTILs	HE	NR	DFS/OS/DRFI	127.2
Dieci, M. V [18].	2014	France/Italy	retrospective	278	NAC/adjuvant	post-NAC	iTILs+sTILs	HE	NR	MFS/OS	75.6
Perez, E. A [19].	2016	USA	RCT	945	adjuvant	resection tissue	sTILs	HE	NR	RFS	52.8
Dieci, M. V [20].	2015	France	RCT	781	adjuvant	resection tissue	iTILs+sTILs	HE	NR	OS/DFS	152.4
Loi, S [5].	2013	Belgium	RCT	2009	adjuvant	resection tissue	iTILs+sTILs	HE	NR	DFS/OS	96
Loi, S [21].	2014	Finnish	retrospective	934	adjuvant	resection tissue	sTILs	HE	NR	DDFS/OS	62
Yasmin Issa-Nummer [22]	2013	Germany	RCT	313	NAC	pre-NAC	iTILs+sTILs	HE	NR	pCR	NR
Denkert, C [4].	2010	Germany	RCT	1058	NAC	pre-NAC	iTILs+sTILs	HE	NR	pCR	NR
Denkert, C [23].	2015	Germany	RCT	580	NAC	pre-NAC	iTILs+sTILs	HE	NR	pCR	NR
Pruneri, G [24].	2016	Italy	RCT	647	adjuvant	resection tissue	sTILs	HE	NR	BCFI / DFS / DRFI / OS	82.8
Ingold Heppner, B [25].	2016	Germany	RCT	498	NAC	pre-NAC	sTILs	HE	NR	pCR / DFS	60.4 (59.5–61.3)
Denkert, C [26].	2018	Germany	RCT	3771	NAC	pre-NAC	sTILs	HE	NR	pCR / DFS / OS	62.8
Wang, Qiong [27]	2020	China	retrospective	75	NAC	pre-NAC/post-NAC	sTILs	HE/IHC	YES	pCR / DFS	23.2 (6.1–64.5)
Brodsky, Alexander S [28].	2016	USA	retrospective	50	NAC + H	pre-NAC	sTILs	HE	NR	pCR	127.2
Leon-Ferre, Roberto A [29].	2018	USA	retrospective	605	adjuvant	resection tissue	iTILs+sTILs	HE	YES	IDFS / OS	127.2
Salgado, Roberto [30]	2015	Australia	RCT	387	NAC + H/L	pre-NAC	sTILs	HE	NR	EFS/ pCR	45.2 (42–50.6)
Ignatiadis, Michail [31]	2019	Belgium	RCT	213	NAC	pre-NAC/post-NAC	sTILs	HE	NR	pCR / EFS	56.4
Mori, H [32].	2017	Japan	retrospective	248	adjuvant	resection tissue	sTILs	HE	YES	RFS / OS	68 (2–150)
Dieci, M. V [33].	2016	Italy	retrospective	105	NAC	pre-NAC/post-NAC	iTILs+sTILs	HE	YES	pCR / EFS	NR
Ruan, Miao [34]	2018	China	retrospective	166	NAC	pre-NAC	iTILs+sTILs	HE	YES	pCR	NR
O’Loughlin, Mark [35]	2018	Ireland	retrospective	75	NAC	pre-NAC	sTILs	HE	NR	pCR	NR
Ali, H. Raza [36]	2016	UK	RCT	614	NAC	pre-NAC/post-NAC	sTILs	HE	NR	pCR	NR
Song, I. H [37].	2017	Korea	retrospective	108	NAC	pre-NAC/post-NAC	sTILs	HE/IHC	YES	pCR/DFS	31.4 (21.1–53.0)
Li, X [38].	2016	USA	retrospective	129	NAC + H	pre-NAC	iTILs+sTILs	HE	YES	pCR	NR
Würfel, F [39].	2018	Germany	retrospective	146	NAC	pre-NAC	sTILs	HE	NR	pCR	NR
Hamy, A. S [40].	2019	France	retrospective	718	NAC ± H	pre-NAC/post-NAC	sTILs	HE	YES	pCR/DFS/OS	NR
Khoury, T [41].	2018	USA	retrospective	331	NAC	pre-NAC	iTILs+sTILs	HE	NR	pCR	NR

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