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Table 5 Ultrasound (A) and histopathological (B) features of PTC patients divided into two age subgroups according cut-off point 45 years old and cut-off point 55 years old. Data are presented as the number of observations (percent)

From: The age threshold of the 8th edition AJCC classification is useful for indicating patients with aggressive papillary thyroid cancer in clinical practice

Variables

Cut-off point 45 years old

Cut-off point 55 years old

PTC patients

<  45 years old

(n = 193)

PTC patients

> 45 years old

(n = 330)

p-value

PTC patients

< 55 years old

(n = 306)

PTC patients

> 55 years old

(n = 217)

p-value

(A) Ultrasonography

Tumor shape

  

0.006a

  

0.025a

Regular

109 (56.5)

145 (43.9)

 

162 (52.9)

93 (42.9)

 

Irregular

84 (43.5)

185 (56.1)

 

144 (47.1)

124 (57.1)

 

Sharpen margins

  

0.004a

  

0.009a

Yes

108 (56.0)

142 (42.9)

 

161 (52.6)

89 (41.0)

 

No

85 (44.0)

188 (57.1)

 

145 (47.4)

128 (59.0)

 

Microcalcifications:

  

< 0.0001a

  

< 0.0001a

Yes

67 (34.7)

232 (70.3)

 

116 (37.9)

183 (84.3)

 

No

126 (65.3)

98 (29.7)

 

190 (62.1)

34 (15.7)

 

Echogenicity:

  

0.005a

  

0.143

Hyperechoic

49 (25.4)

51 (15.5)

 

65 (21.2)

35 (16.1)

 

Hypoechoic

144 (74.6)

279 (84.6)

 

241 (78.8)

182 (83.9)

 

Vascularity:

  

0.002a

  

0.007a

High

82 (42.5)

188 (57.0)

 

142 (46.4)

127 (58.5)

 

Low

111 (57.5)

142 (43.0)

 

164 (53.6)

90 (41.5)

 

(B) Histopathology

Extrathyroidal extension:

  

< 0.0001a

  

< 0.0001a

Yes

38 (19.7)

147 (44.6)

 

66 (21.6)

119 (54.8)

 

No

155 (80.3)

183 (55.5)

 

240 (78.4)

98 (45.2)

 

Capsular invasion:

  

< 0.0001a

  

< 0.0001a

Yes

38 (19.7)

147 (44.6)

 

66 (21.6)

119 (54.8)

 

No

155 (80.3)

183 (55.5)

 

240 (78.4)

98 (45.2)

 

Vascular invasion

  

< 0.0001a

  

< 0.0001a

Yes

38 (19.7)

147 (44.6)

 

66 (21.6)

119 (54.8)

 

No

155 (80.3)

183 (55.5)

 

240 (78.4)

98 (45.2)

 

Diagnosed as multifocal:

  

0.002a

  

0.036a

No

156 (80.8)

224 (67.9)

 

233 (76.1)

147 (67.7)

 

yes

37 (19.2)

106 (32.1)

 

73 (23.9)

70 (32.3)

 

Diagnosed as bilateral:

  

0.004a

  

0.002a

No

186 (96.4)

294 (89.1)

 

291 (95.1)

190 (87.6)

 

Yes

7 (3.6)

36 (10.9)

 

15 (4.9)

27 (12.4)

 

Number of foci:

  

0.004a

  

0.0005a

1

169 (87.6)

255 (77.3)

 

259 (84.6)

165 (76.0)

 

2

22 (11.4)

56 (17.0)

 

43 (14.1)

35 (16.2)

 

3

2 (1.0)

19 (5.7)

 

4 (1.3)

17 (7.8)

 

4

0 (0.0)

0 (0.0)

 

0 (0.0)

0 (0.0)

 
  1. a- statistically significant