From: Impact of prior cancer history on the survival of patients with larynx cancer
Characteristic | Overall survival | Larynx cancer-specific mortality | ||
---|---|---|---|---|
AHR (95% CI) | P value | AHR (95% CI) | P value | |
All patient after PSM | ||||
Primary larynx cancer | 1.0 (Ref) | 1.0 (Ref) | ||
Second larynx cancer | 1.30 (1.21–1.41) | <.001 | 0.83 (0.72–0.94) | 0.004 |
Subgroup with prior cancer | ||||
Age | ||||
< 45 | 1.0 (Ref) | 1.0 (Ref) | ||
45–64 | 1.12 (0.53–2.39) | 0.765 | 2.98 (0.39–22.6) | 0.290 |
> 64 | 1.60 (0.76–3.38) | 0.216 | 3.86 (0.51–29.3) | 0.190 |
Gender | ||||
Male | 1.0 (Ref) | 1.0 (Ref) | ||
Female | 0.89 (0.78–1.03) | 0.111 | 0.85 (0.65–1.10) | 0.210 |
Race | ||||
White | 1.0 (Ref) | 1.0 (Ref) | ||
Black | 0.99 (0.87–1.15) | 0.986 | 1.15 (0.89–1.48) | 0.290 |
Others/Unknown | 0.81 (0.60–1.09) | 0.164 | 1.43 (0.93–2.22) | 0.110 |
Marital status | ||||
Single | 1.0 (Ref) | 1.0 (Ref) | ||
Married | 0.73 (0.62–0.85) | <.001 | 0.75 (0.56–0.98) | 0.040 |
Other status a | 1.09 (0.92–1.29) | 0.303 | 1.03 (0.77–1.40) | 0.830 |
Unknown | 0.79 (0.61–1.02) | 0.072 | 0.59 (0.35–1.01) | 0.053 |
AJCC stage | ||||
I | 1.0 (Ref) | 1.0 (Ref) | ||
II | 1.73 (1.46–2.05) | <.001 | 2.00 (1.39–2.88) | <.001 |
III | 2.58 (2.19–3.05) | <.001 | 3.22 (2.29–4.54) | <.001 |
IV | 3.95 (3.37–4.63) | <.001 | 5.23 (3.80–7.19) | <.001 |
Unknown | 1.59 (1.28–1.97) | <.001 | 2.57 (1.70–3.88) | <.001 |
Histological grade | ||||
Grade I | 1.0 (Ref) | 1.0 (Ref) | ||
Grade II | 1.04 (0.87–1.24) | 0.665 | 1.06 (0.75–1.50) | 0.760 |
Grade III | 1.19 (0.98–1.44) | 0.085 | 1.05 (0.72–1.52) | 0.820 |
Grade IV | 2.42 (1.39–4.20) | 0.002 | 0.94 (0.28–3.23) | 0.920 |
Unknown | 1.12 (0.93–1.35) | 0.238 | 0.98 (0.67–1.41) | 0.890 |
Surgery | ||||
No surgery | 1.0 (Ref) | 1.0 (Ref) | ||
Surgery | 0.57 (0.50–0.64) | <.001 | 0.68 (0.54–0.85) | <.001 |
Chemotherapy | ||||
No chemotherapy | 1.0 (Ref) | 1.0 (Ref) | ||
Chemotherapy | 0.82 (0.71–0.95) | 0.006 | 0.94 (0.73–1.20) | 0.610 |
Radiotherapy | ||||
No radiation | 1.0 (Ref) | 1.0 (Ref) | ||
Radiation | 0.56 (0.49–0.63) | <.001 | 0.67 (0.56–0.88) | 0.002 |