Table 4 Comprehensive multivariable-adjusted Hazard Ratios for overall survival and larynx cancer-specific mortality

 Primary larynx cancer

1.0 (Ref)

1.0 (Ref)

 Second larynx cancer

1.30 (1.21–1.41)

<.001

0.83 (0.72–0.94)

0.004

   < 45

1.0 (Ref)

1.0 (Ref)

  45–64

1.12 (0.53–2.39)

0.765

2.98 (0.39–22.6)

0.290

   > 64

1.60 (0.76–3.38)

0.216

3.86 (0.51–29.3)

0.190

  Male

1.0 (Ref)

1.0 (Ref)

  Female

0.89 (0.78–1.03)

0.111

0.85 (0.65–1.10)

0.210

  White

1.0 (Ref)

1.0 (Ref)

  Black

0.99 (0.87–1.15)

0.986

1.15 (0.89–1.48)

0.290

  Others/Unknown

0.81 (0.60–1.09)

0.164

1.43 (0.93–2.22)

0.110

  Single

1.0 (Ref)

1.0 (Ref)

  Married

0.73 (0.62–0.85)

<.001

0.75 (0.56–0.98)

0.040

  Other status ^a

1.09 (0.92–1.29)

0.303

1.03 (0.77–1.40)

0.830

  Unknown

0.79 (0.61–1.02)

0.072

0.59 (0.35–1.01)

0.053

  I

1.0 (Ref)

1.0 (Ref)

  II

1.73 (1.46–2.05)

<.001

2.00 (1.39–2.88)

<.001

  III

2.58 (2.19–3.05)

<.001

3.22 (2.29–4.54)

<.001

  IV

3.95 (3.37–4.63)

<.001

5.23 (3.80–7.19)

<.001

  Unknown

1.59 (1.28–1.97)

<.001

2.57 (1.70–3.88)

<.001

  Grade I

1.0 (Ref)

1.0 (Ref)

  Grade II

1.04 (0.87–1.24)

0.665

1.06 (0.75–1.50)

0.760

  Grade III

1.19 (0.98–1.44)

0.085

1.05 (0.72–1.52)

0.820

  Grade IV

2.42 (1.39–4.20)

0.002

0.94 (0.28–3.23)

0.920

  Unknown

1.12 (0.93–1.35)

0.238

0.98 (0.67–1.41)

0.890

  No surgery

1.0 (Ref)

1.0 (Ref)

  Surgery

0.57 (0.50–0.64)

<.001

0.68 (0.54–0.85)

<.001

  No chemotherapy

1.0 (Ref)

1.0 (Ref)

  Chemotherapy

0.82 (0.71–0.95)

0.006

0.94 (0.73–1.20)

0.610

  No radiation

1.0 (Ref)

1.0 (Ref)

  Radiation

0.56 (0.49–0.63)

<.001

0.67 (0.56–0.88)

0.002