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Table 4 Comprehensive multivariable-adjusted Hazard Ratios for overall survival and larynx cancer-specific mortality

From: Impact of prior cancer history on the survival of patients with larynx cancer

Characteristic Overall survival Larynx cancer-specific mortality
AHR (95% CI) P value AHR (95% CI) P value
All patient after PSM
 Primary larynx cancer 1.0 (Ref)   1.0 (Ref)  
 Second larynx cancer 1.30 (1.21–1.41) <.001 0.83 (0.72–0.94) 0.004
Subgroup with prior cancer
 Age
   < 45 1.0 (Ref)   1.0 (Ref)  
  45–64 1.12 (0.53–2.39) 0.765 2.98 (0.39–22.6) 0.290
   > 64 1.60 (0.76–3.38) 0.216 3.86 (0.51–29.3) 0.190
 Gender
  Male 1.0 (Ref)   1.0 (Ref)  
  Female 0.89 (0.78–1.03) 0.111 0.85 (0.65–1.10) 0.210
 Race
  White 1.0 (Ref)   1.0 (Ref)  
  Black 0.99 (0.87–1.15) 0.986 1.15 (0.89–1.48) 0.290
  Others/Unknown 0.81 (0.60–1.09) 0.164 1.43 (0.93–2.22) 0.110
 Marital status
  Single 1.0 (Ref)   1.0 (Ref)  
  Married 0.73 (0.62–0.85) <.001 0.75 (0.56–0.98) 0.040
  Other status a 1.09 (0.92–1.29) 0.303 1.03 (0.77–1.40) 0.830
  Unknown 0.79 (0.61–1.02) 0.072 0.59 (0.35–1.01) 0.053
 AJCC stage
  I 1.0 (Ref)   1.0 (Ref)  
  II 1.73 (1.46–2.05) <.001 2.00 (1.39–2.88) <.001
  III 2.58 (2.19–3.05) <.001 3.22 (2.29–4.54) <.001
  IV 3.95 (3.37–4.63) <.001 5.23 (3.80–7.19) <.001
  Unknown 1.59 (1.28–1.97) <.001 2.57 (1.70–3.88) <.001
 Histological grade
  Grade I 1.0 (Ref)   1.0 (Ref)  
  Grade II 1.04 (0.87–1.24) 0.665 1.06 (0.75–1.50) 0.760
  Grade III 1.19 (0.98–1.44) 0.085 1.05 (0.72–1.52) 0.820
  Grade IV 2.42 (1.39–4.20) 0.002 0.94 (0.28–3.23) 0.920
  Unknown 1.12 (0.93–1.35) 0.238 0.98 (0.67–1.41) 0.890
 Surgery
  No surgery 1.0 (Ref)   1.0 (Ref)  
  Surgery 0.57 (0.50–0.64) <.001 0.68 (0.54–0.85) <.001
 Chemotherapy
  No chemotherapy 1.0 (Ref)   1.0 (Ref)  
  Chemotherapy 0.82 (0.71–0.95) 0.006 0.94 (0.73–1.20) 0.610
 Radiotherapy
  No radiation 1.0 (Ref)   1.0 (Ref)  
  Radiation 0.56 (0.49–0.63) <.001 0.67 (0.56–0.88) 0.002
  1. Abbreviations: AHR adjusted hazard ratio, Ref reference category
  2. Note: The multivariate analysis was adjusted for age, race, marital status, histologic grade, AJCC T stage, and treatment modalities (surgery, chemotherapy, and radiation)
  3. a other status including divorced, widowed, separated or domestic partner