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Table 1 Sequential or concurrent dosing schedule in Rb WT and KD MCF-7 cells

From: Exploring treatment with Ribociclib alone or in sequence/combination with Everolimus in ER+HER2Rb wild-type and knock-down in breast cancer cell lines

A) Sequential dosing schedule

 

3 days

2 days

1

Ribociclib

Vehicle

2

Ribociclib

Everolimus

3

Everolimus

Vehicle

4

Everolimus

Ribociclib

B) Concurrent dosing schedule

 

3 days

1

Ribociclib + Everolimus

2

Ribociclib + Vehicle

3

Everolimus + Vehicle

  1. A) Sequential dosing schedule of combination of Rib and Eve; B) Concurrent dosing schedule of combination of Rib and Eve