From: Exploring treatment with Ribociclib alone or in sequence/combination with Everolimus in ER+HER2−Rb wild-type and knock-down in breast cancer cell lines
A) Sequential dosing schedule
3 days
2 days
1
Ribociclib
Vehicle
2
Everolimus
3
4
B) Concurrent dosing schedule
Ribociclib + Everolimus
Ribociclib + Vehicle
Everolimus + Vehicle