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Table 3 The comparison of dosimetric parameters between original and accumulated plans

From: Accumulation of the delivered dose based on cone-beam CT and deformable image registration for non-small cell lung cancer treated with hypofractionated radiotherapy

 

Original plan (mean ± SD)

Accumulated plan (mean ± SD)

P value

Relative change (median, range)

Above 5% relative reduction/increase*

PTV-GTV

 V51 (%)

88.2 ± 6

87.6 ± 6.3

0.452

−0.1% (−10–6%)

3 (11.1%)

 D95 (Gy)

48.1 ± 2.0

48.0 ± 2.3

0.781

0.1% (−7.6–5%)

1 (3.7%)

 Dmean (Gy)

52.6 ± 0.5

52.6 ± 0.6

0.873

0.04% (−1–1%)

0

Total lung

 V20 (%)

29.5 ± 4.2

30.1 ± 4.1

0.001

1.6% (−3–9%)

3 (11.1%)

 V30 (%)

19.9 ± 4.4

20.4 ± 4.4

0.004

1.9% (−3–16%)

6 (22.2%)

 Dmean (Gy)

16.8 ± 2.1

17.0 ± 2.1

0.001

1.4% (−2–5%)

1 (3.7%)

Esophagus

 Dmax (Gy)

47.4 ± 1.3

49.5 ± 1.8

<0.001

4.1% (−4–15%)

10 (37.0%)

 Dmean (Gy)

26.6 ± 4.2

27.1 ± 4.0

0.002

1.4% (−2–5%)

1 (3.7%)

Heart

 V30 (%)

13.0 ± 10.1

12.9 ± 10.9

0.675

−17.4% (−48.6–16.4%)

7 (25.9%)

 V40 (%)

5.2 ± 5.0

4.9 ± 5.1

0.168

−7.1% (−73.9–26.4%)

8 (29.6%)

 Dmean (Gy)

13.0 ± 6.7

13.1 ± 7.0

0.558

1% (−1.9–12.4%)

5 (18.5%)

  1. #Relative change = (Accumulated plan-Original plan)/Original plan×100%
  2. *Number of patients who had above 5% reduction in PTV-GTV dosage or above 5% increase in OARs dosage