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Table 3 The comparison of dosimetric parameters between original and accumulated plans

From: Accumulation of the delivered dose based on cone-beam CT and deformable image registration for non-small cell lung cancer treated with hypofractionated radiotherapy

  Original plan (mean ± SD) Accumulated plan (mean ± SD) P value Relative change (median, range) Above 5% relative reduction/increase*
PTV-GTV
 V51 (%) 88.2 ± 6 87.6 ± 6.3 0.452 −0.1% (−10–6%) 3 (11.1%)
 D95 (Gy) 48.1 ± 2.0 48.0 ± 2.3 0.781 0.1% (−7.6–5%) 1 (3.7%)
 Dmean (Gy) 52.6 ± 0.5 52.6 ± 0.6 0.873 0.04% (−1–1%) 0
Total lung
 V20 (%) 29.5 ± 4.2 30.1 ± 4.1 0.001 1.6% (−3–9%) 3 (11.1%)
 V30 (%) 19.9 ± 4.4 20.4 ± 4.4 0.004 1.9% (−3–16%) 6 (22.2%)
 Dmean (Gy) 16.8 ± 2.1 17.0 ± 2.1 0.001 1.4% (−2–5%) 1 (3.7%)
Esophagus
 Dmax (Gy) 47.4 ± 1.3 49.5 ± 1.8 <0.001 4.1% (−4–15%) 10 (37.0%)
 Dmean (Gy) 26.6 ± 4.2 27.1 ± 4.0 0.002 1.4% (−2–5%) 1 (3.7%)
Heart
 V30 (%) 13.0 ± 10.1 12.9 ± 10.9 0.675 −17.4% (−48.6–16.4%) 7 (25.9%)
 V40 (%) 5.2 ± 5.0 4.9 ± 5.1 0.168 −7.1% (−73.9–26.4%) 8 (29.6%)
 Dmean (Gy) 13.0 ± 6.7 13.1 ± 7.0 0.558 1% (−1.9–12.4%) 5 (18.5%)
  1. #Relative change = (Accumulated plan-Original plan)/Original plan×100%
  2. *Number of patients who had above 5% reduction in PTV-GTV dosage or above 5% increase in OARs dosage
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