Table 3 Pooled risk estimates for SNPs TNF-α −1031 T/C, −863 C/A, −857 C/T, −308 G/A, and − 238 G/A with HCC risk

−1031 T/C

 C vs T

3

1.06 [0.89–1.26]

0.52

0.77

0

 CC + TC vs TT

5

1.04 [0.86–1.27]

0.69

0.97

0

 CC vs TT

3

1.39 [0.88–2.18]

0.15

0.99

0

 CC vs TC + TT

3

1.41 [0.91–2.21]

0.13

1

0

 TC vs TT

3

0.96 [0.77–1.19]

0.70

0.64

0

−863 C/A

 A vs C

7

1.31 [1.03–1.67]

0.03*

0.007

66

 AA+CA vs CC

8

1.19 [1.03–1.36]

0.02*

0.35

10

 AA vs CC

7

1.43 [0.98–2.10]

0.07

0.50

0

 AA vs CA + CC

7

1.28 [0.89–1.86]

0.19

0.84

0

 CA vs CC

7

1.41 [1.00–1.99]

0.05

0.0007

74

−857 C/T

 T vs C

4

1.16 [0.94–1.43]

0.17

0.45

0

 TT + CT vs CC

5

1.31 [1.06–1.62]

0.01*

0.24

27

 TT vs CC

4

0.75 [0.42–1.36]

0.35

0.87

0

 TT vs CT + CC

4

0.77 [0.44–1.35]

0.36

0.77

0

 CT vs CC

4

1.02 [0.77–1.34]

0.89

0.54

0

−308 G/A

 A vs G

17

1.98 [1.62–2.42]

< 0.001*

0.03

44

 AA+GA vs GG

19

1.95 [1.53–2.49]

< 0.001*

0.003

54

 AA vs GG

13

3.14 [2.06–4.79]

< 0.001*

0.69

0

 AA vs GA + GG

13

2.52 [1.69–3.76]

< 0.001*

0.81

0

 GA vs GG

17

2.07 [1.60–2.68]

< 0.001*

0.006

52

−238 G/A

 A vs G

8

1.50 [1.16–1.94]

0.002*

0.07

46

 AA+GA vs GG

9

1.39 [0.87–2.24]

0.17

0.03

52

 AA vs GG

5

3.87 [1.32–11.34]

0.01*

0.70

0

 AA vs GA + GG

8

2.67 [1.17–6.10]

0.02*

0.87

0

 GA vs GG

8

1.28 [0.72–2.28]

0.39

0.01

61