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Table 5 Genotype frequencies of KCNB1 SNPs and related indel

From: Western influenced lifestyle and Kv2.1 association as predicted biomarkers for Tunisian colorectal cancer

SNPs

Total population

Stratification according to sex

Stratification according to tumor site

Colorectal cancer (CRC)

Males

Females

Colon Cancer (CC)

Rectum Cancer (RC)

Cases n = 300(%)

Controls n = 300(%)

P

OR

CI (95%)

Cases n = 153(%)

P

OR

CI (95%)

Cases n = 157(%)

P

OR

CI (95%)

Cases n = 190(%)

P

OR

CI (95%)

Cases n = 110(%)

P

OR

CI (95%)

rs3331

 T/T

77 (25.7)

106 (35.3)

0.005

1.00

Ref

36 (24.7)

0.47

1.00

Ref

41 (26.6)

0.012

1.00

Ref

51 (26.8)

0.02

1.00

Ref

26 (23.6)

0.03

1.00

Ref

 T/C

171 (57)

132 (44)

1.78

1.23–2.59

82 (56.1)

1.44

0.78–2.68

89 (57.8)

1.92

1.19–3.12

108 (56.8)

1.70

1.12–2.59

63 (57.3)

1.94

1.16–3.23

 C/Ca

52 (17.3)

62 (20.7)

1.15

0.72–1.84

28 (19.2)

1.14

0.53–2.47

24 (15.6)

1.06

0.56–1.98

31 (16.4)

1.03

0.59–1.78

21 (19.1)

138

0.71–2.65

rs1051295

 A/A

46 (15.3)

84 (28.0)

< 0.001

1.00

Ref

25 (17.1)

< 0.001

1.00

Ref

21 (13.6)

< 0.001

1.00

Ref

30 (15.8)

< 0.001

1.00

Ref

16 (14.6)

< 0.001

1.00

Ref

 A/G

192 (64)

107 (35.7)

3.27

2.14–5.06

96 (65.8)

3.71

1,90–7.35

96 (62.4)

3.26

1.84–5.96

122 (64.2)

3.19

1.97–5.27

70 (63.6)

3.43

1.89–6.52

 G/Ga

62 (20.7)

109 (36.3)

1.03

0.64–1.67

25 (17.1)

0.90

0.42–1.91

37 (24.0)

1.25

0.66–2.40

38 (20)

0.97

0.56–1.71

24 (21.8)

1.15

0.58–2.34

rs11468831

 ins/ins

135 (45)

71 (23.7)

< 0.001

1.00

Ref

59 (40.4)

0.01

1.00

Ref

76 (49.4)

< 0.001

1.00

Ref

91 (47.9)

< 0.001

1.00

Ref

44 (40)

0.004

1.00

Ref

 ins/del

78 (26)

98 (32.7)

0.41

0.27–0.63

42 (28.2)

0.61

0.30–1.2

36 (23.4)

0.32

0.18–0.55

48 (25.3)

0.38

0.23–0,60

30 (27.3)

0.49

0.28–0.85

 del/dela

87 (29)

131 (43)

0.34

0.23–0.51

45 (30.8)

0.39

020–0.75

42 (27.2)

0.30

018–0.50

51 (26.8)

0.30

0.19–0.47

36 (32.7)

–

0,44 (2–0,8)

  1. Value in bold is statistically significant at 0.05 level of significance
  2. SNPs Single Nucleotide Polymorphisms, Ref Reference, OR Odds Ratio, CI Confidence Interval (95%),
  3. P p value comparing healthy controls vs. Cases (CRC, RC, CC)
  4. a minor genotype
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