Western influenced lifestyle and Kv2.1 association as predicted biomarkers for Tunisian colorectal cancer

BMC Cancer

Table 4 Allele frequencies of KCNB1 SNPs and related Indel

SNPs	Total population						Stratification according to sex										Stratification according to tumor site
	Colorectal cancer (CRC)						Males					Females					Colon Cancer (CC)					Rectum Cancer (RC)
	Cases n = 300(%)	Controls n = 300(%)	P	P^a	OR	CI (95%)	Cases n = 146(%)	P	P^a	OR	CI (95%)	Cases n = 154(%)	P	P^a	OR	CI (95%)	Cases n = 190(%)	P	P^a	OR	CI (95%)	Cases n = 110(%)	P	P^a	OR	CI (95%)
rs3331
T	325 (54)	344 (57)	0.147	0.05	1.00	Ref	154 (53)	0.11	0.18	1.00	Ref	171 (56)	0.325	0.077	1.00	Ref	210 (55)	0.283	0.08	1.00	Ref	115 (52)	0.112	0.09	1.00	Ref
C^a	275 (46)	256 (43)	0.147	0.05	1.08	[1.0–1.17]	138 (47)	0.11	0.18	1.10	[0.95–1.27]	137 (44)	0.325	0.077	1.05	[0.95–1.17]	170 (45)	0.283	0.08	1.16	[0.82–1.65]	105 (48)	0.112	0.09	1.09	[0.98–1.22]
rs1051295
A	284 (47)	275 (46)	0.32	0.148	1.00	Ref	146 (50)	0.13	0.07	1.00	Ref	138 (45)	0.411	0.18	1.00	Ref	182 (48)	0.29	0.319	1.00	Ref	102 (46)	0.477	0.07	1.00	Ref
G^a	316 (46)	325 (54)	0.32	0.148	0.93	[0.86–1.02]	146 (50)	0.13	0.07	0.87	[0.75–1.01]	170 (55)	0.411	0.18	0.93	[0.83–1.03]	198 (52)	0.29	0.319	0.95	[0.86–1.04]	118 (54)	0.477	0.07	0.90	[0.81–1.00]
rs11468831
ins	348 (58)	240 (40)	< 0.01	< 0.001	1.00	Ref	160 (55)	< 0.01	< 0.001	1.00	Ref	188 (61)	< 0.01	< 0.001	1.00	Ref	230 (60)	< 0.01	< 0.01	1.00	Ref	118 (54)	< 0.01	0.005	1.00	Ref
del^a	252 (42)	360 (60)	< 0.01	< 0.001	0.80	[0.74–0.87]	132 (45)	< 0.01	< 0.001	0.747	[0.64–0.86]	120 (39)	< 0.01	< 0.001	0.83	[0.74–0.92]	150 (40)	< 0.01	< 0.01	0.79	[0.72–0.87]	102 (46)	< 0.01	0.005	0.85	[0.76–0.95]

Value in bold is statistically significant at 0.05 level of significance
SNPs Single Nucleotide Polymorphisms, Ref Reference, OR Odds Ratio, CI Confidence Interval (95%)
P p value comparing all Controls vs. Cases (CRC, RC, CC)
P^a: p value adjusted for CRC and RC p value was adjusted for gender, physical activity level, tobacco use, alcohol use, meat and fat consumption, for CC p value was adjusted for gender, physical activity level, tobacco use, alcohol use, and for brine, meat and fat consumption
^a minor allele

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