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Table 2 Standardized incidence ratios and excess risk for the diagnosis of t-AML after lung cancer

From: Clinicopathological features, risk and survival in lung cancer survivors with therapy-related acute myeloid leukaemia

Characteristic

n (%)

SIR (95% CI)

ER (per 10,000)

Person-years at risk

Sex

 Male

52 (50.0)

3.20 (2.41–4.16)*

3.26

116,136.88

 Female

52 (50.0)

5.36 (4.03–7.00)*

4.10

107,177.52

Age

 < 65 years

58 (55.8)

9.08 (6.74–11.97)*

4.24

104,996.47

 ≥ 65 years

46 (44.2)

2.71 (2.07–3.50)*

3.15

118,317.93

Latency period

 2–11 months

11 (10.6)

1.12 (0.56–2.00)

0.13

86,808.04

 12–35 months

41 (39.4)

5.35 (3.87–7.21)*

5.15

67,848.48

 36–59 months

31 (29.8)

9.29 (6.35–13.11)*

10.54

27,090.39

 60+ months

21 (20.2)

3.88 (2.46–5.82)*

4.11

41,567.48

Period of diagnosis

 1975–1984

7 (6.7)

5.99 (2.41–12.35)*

4.26

13,687.57

 1985–1994

12 (11.5)

4.19 (2.23–7.17)*

3.01

32,838.60

 1995–2004

29 (27.9)

4.05 (2.73–5.78)*

3.61

62,575.81

 2005–2015

56 (53.8)

3.79 (2.88–4.88)*

3.80

114,212.42

  1. ER Excess risk, t-AML Therapy-related acute myeloid leukaemia, SIRs Standardized incidence ratios
  2. * Indicates P < 0.05