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Table 2 Univariate analysis of prognostic factors

From: Prognostic factors and survival according to tumour subtype in women presenting with breast cancer bone metastases at initial diagnosis: a SEER-based study

Characteristics Median OS P value HR 95% CI for HR
Age at diagnosis   < 0.001   
 40–44 years 42   Reference  
 45–49 years 41   1.013 0.829–1.237
 50–54 years 39   1.103 0.915–1.329
 55–59 years 32   1.364 1.139–1.634
Race   < 0.001   
 White 41   Reference  
 Black 28   1.498 1.315–1.707
 Other a 38   1.003 0.824–1.220
Marital status   < 0.001   
 Single 32   Reference  
 Married 42   0.723 0.638–0.819
 Other b 35   0.903 0.772–1.057
Insurance   < 0.001   
 Uninsured 26   Reference  
 Insured 38   0.633 0.513–0.781
Grade   < 0.001   
 I 48   Reference  
 II 44   1.214 0.953–1.547
 III or IV 28   2.071 1.634–2.625
Histology   0.003   
 Ductal 36   Reference  
 Lobular 44   0.748 0.624–0.897
 Others 40   0.856 0.713–1.028
Laterality   0.084   
 Right 38   Reference  
 Left 38   1.058 0.949–1.179
 Bilateral, single primary 13   2.254 1.008–5.039
Tumour subtype   < 0.001   
 HR+/HER2- 39   Reference  
 HR+/HER2+ 52   0.747 0.640–0.873
 HR−/HER2- 11   3.571 3.071–4.152
 HR−/HER2+ 35   1.132 0.917–1.397
Bone+Lung metastases   < 0.001   
 No 42   Reference  
 Yes 23   1.888 1.679–2.123
Bone+Liver metastases   < 0.001   
 No 44   Reference  
 Yes 22   2.182 1.950–2.443
Bone+Brain metastases   < 0.001   
 No 40   Reference  
 Yes 14   2.674 2.245–3.184
Only bone metastases   < 0.001   
 No 46   Reference  
 Yes 24   2.29 2.04–2.559
Surgery   < 0.001   
 No 32   Reference  
 Yes 52   0.496 0.433–0.568
  1. Other a (American Indian/AK Native, Asian/Pacific Islander)
  2. Other b (divorced/widowed/separated).
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