Table 1 Baseline characteristics of patients
No. of patients (%) or Mean ± SD (n = 210) | |
|---|---|
Age | |
Mean ± SD (years) | 67.1 ± 11.1 |
≥ 65 years (%) | 132 (62.9) |
Sex | |
Men | 102 (48.6) |
Body mass index | |
Median (range) | 22.4 (15.7–38.3) |
ISS stage | |
I | 39 (18.6) |
II | 94 (44.8) |
III | 77 (36.7) |
Measurable serum M protein | |
IgG | 121 (57.6) |
IgA | 40 (19.1) |
IgD | 7 (3.3) |
Light chain | 41 (19.5) |
Non-secretory | 1 (0.5) |
Involved free light chain | |
Type of free light chain | |
kappa | 126 (64.6) |
lambda | 69 (35.4) |
Unknown | 15 |
Mean ± SD (mg/L)a | |
kappa | 2494.3 ± 3901.5 |
lambda | 1629.6 ± 3017.4 |
Plasma cells in bone marrow (%) b | |
Mean ± SD | 32.2 ± 22.7 |
Presence of plasma cell in peripheral blood | |
Presence | 25 (11.9) |
Presence of extramedullary disease c | |
Presence | 13 (7.4) |
Baseline laboratory data (Blood tests) | |
Lactic dehydrogenase (U/L) | |
Mean ± SD | 210.8 ± 132.3 |
Creatinine (mg/dL) | |
Mean ± SD | 1.19 ± 0.99 |
Estimated glomerular filtration rate (mL/min/1.73 m2) | |
Mean ± SD | 61.7 ± 30.3 |
Uric acid (mg/dL) | |
Mean ± SD | 5.8 ± 1.8 |
Potassium (mmol/L) | |
Mean ± SD | 4.1 ± 0.4 |
Phosphorus (mg/dL) d | |
Mean ± SD | 3.6 ± 0.7 |
β2 microglobulin | |
Mean ± SD (μg/mL) | 5.7 ± 3.9 |
Albumin | |
Mean ± SD (g/dL) | 3.2 ± 0.7 |
Calcium | |
Mean ± SD (mg/dL) | 9.1 ± 0.9 |
Incidence of TLS e | |
Laboratory TLS | 10 (4.8) |
Clinical TLS | 7 (3.3) |