Table 2 Univariable and multivariable Cox regression analysis of OS for metastatic RCC patients

Age

1.01 (1.00–1.02)

0.025

 White

Ref.

 Black

1.26 (0.99–1.61)

0.06

 Other

1.08 (0.84–1.38)

0.561

 Male

Ref.

 Female

1.07 (0.92–1.24)

0.383

 Married

Ref.

 Unmarried

1.12 (0.97–1.30)

0.117

 CCRCC

Ref.

 PRCC

1.28 (0.95–1.74)

0.106

 CHRCC

1.06 (0.55–2.04)

0.874

 SRCC

2.25 (1.78–2.85)

< 0.001

 CDRCC

2.37 (1.40–4.03)

0.001

 Grade I

Ref.

Ref.

 Grade II

0.81 (0.48–1.35)

0.411

1.04 (0.62–1.76)

 Grade III

0.94 (0.57–1.55)

0.809

1.34 (0.80–2.25)

 Grade IV

1.46 (0.88–2.41)

0.142

1.73 (1.02–2.95)

Tumor size

1.001 (1.000–1.002)

0.002

 T1

Ref.

 T2

1.42 (1.08–1.87)

0.013

 T3

1.47 (1.16–1.86)

0.002

 T4

2.43 (1.83–3.23)

< 0.001

 TX

5.63 (3.18–9.97)

< 0.001

 N0

Ref.

Ref.

 N1

1.87 (1.61–2.18)

< 0.001

1.55 (1.32–1.81)

 NX

1.85 (1.35–2.53)

< 0.001

1.62 (1.17–2.25)

 Yes

Ref.

Ref.

 No

0.47 (0.40–0.56)

< 0.001

0.61 (0.50–0.74)

 Unknown

1.05 (0.80–1.38)

0.709

0.80 (0.58–1.11)

 Recommended and performed

Ref.

Ref.

 Recommended but not performed

4.37 (2.46–7.76)

< 0.001

4.15 (2.25–7.66)

 Not recommended

2.54 (2.12–3.04)

< 0.001

2.30 (1.85–2.86)

 Yes

Ref.

Ref.

 No

0.80 (0.69–0.93)

0.003

0.68 (0.58–0.79)

 Yes

Ref.

Ref.

 No

0.54 (0.44–0.68)

< 0.001

0.60 (0.48–0.76)

 Yes

Ref.

Ref.

 No

0.54 (0.44–0.66)

< 0.001

0.66 (0.54–0.82)

 Yes

Ref.

Ref.

 No

0.65 (0.56–0.75)

< 0.001

0.64 (0.55–0.75)