Skip to main content

Table 1 Phenotypic and genotypic baseline characteristics of cases and controls in our Spanish cohort

From: Combination of phenotype and polygenic risk score in breast cancer risk evaluation in the Spanish population: a case –control study

Risk Factor Category Description Number % Number % Median SD Median SD OR OR CI 95% P-value
Controls Controls Cases Cases Control Control Cases Cases
Age 0 30–35 years 28 4,36 16 3,52 51 8,18 51 8,14 1,05 0.79–1.13 0,27
1 35–40 years 58 9,03 28 6,15
2 40–45 years 84 13,08 63 13,85
3 45–50 years 138 21,5 115 25,27
4 50–55 years 158 24,61 86 18,9
5 55–60 years 113 17,6 94 20,66
6 60–65 years 47 7,32 37 8,13
7 > 65 years 16 2,49 16 3,52
Breast Density 0 From 0 to 10% 99 15,42 51 11,21 2 1,2 3 1,3 1,46 1.21–1.71 1,64E-07
1 From 11 to 25% 116 18,07 53 11,65
2 From 26 to 50% 185 28,82 116 25,49
3 From 51 to 75% 181 28,19 133 29,23
4 Greater than 75% 61 9,5 102 22,42
Age at first delivery 0 Less than 20 years 33 5,14 23 5,05 2 1,4 2 1,46 1,15 1.02–1.31 0,03
1 From 20 to 24 years 165 25,7 104 22,86
2 From 25 to 29 years 203 31,62 107 23,52
3 From 30 to 34 years 106 16,51 101 22,2
4 Greater than 34 years 56 8,72 50 10,99
5 Nulliparous 79 12,31 70 15,38
Age at menopause 0 Less than 46 years 97 15,11 47 10,33 2 1,4 3 1,13 1,96 1.72–2.24 2,20E-16
1 From 46 to 50 years 147 22,9 102 22,42
2 Greater than 50 years 110 17,13 71 15,6
3 Premenopause 87 13,55 212 46,59
4 Menstruating 201 31,31 23 4,97
Age at menarche 0 Equal to or greater than 15 years 34 5,3 34 7,47 2 1,21 3 1,2 0,89 0.78–1.04 0,061
1 14 years 115 17,91 85 18,68
2 13 years 178 27,73 100 21,98
3 12 years 140 21,81 110 24,18
4 Less than 12 years 175 27,26 123 27,03
5 Null 0 0 3 0,66
Family antecedents 0 No affected relative 468 72,9 308 67,69 0 1,16 0 1,23 1,05 0.93–1.19 0,34
1 A first-degree relative diagnosed with breast cancer at age 50 years or older 52 8,1 43 9,45
2 A first-degree relative diagnosed with breast cancer when younger than 50 years 25 3,89 18 3,96
3 1 affected second-degree relative 90 14,02 79 17,36
4 2 affected first-degree relatives 4 0,62 5 1,1
5 2 affected second-degree relatives 1 0,16 2 0,44
6 3 or more affected relatives 2 0,31 0 0
\