Table 1 Phenotypic and genotypic baseline characteristics of cases and controls in our Spanish cohort

Age

0

30–35 years

28

4,36

16

3,52

51

8,18

51

8,14

1,05

0.79–1.13

0,27

1

35–40 years

58

9,03

28

6,15

2

40–45 years

84

13,08

63

13,85

3

45–50 years

138

21,5

115

25,27

4

50–55 years

158

24,61

86

18,9

5

55–60 years

113

17,6

94

20,66

6

60–65 years

47

7,32

37

8,13

7

> 65 years

16

2,49

16

3,52

Breast Density

0

From 0 to 10%

99

15,42

51

11,21

2

1,2

3

1,3

1,46

1.21–1.71

1,64E-07

1

From 11 to 25%

116

18,07

53

11,65

2

From 26 to 50%

185

28,82

116

25,49

3

From 51 to 75%

181

28,19

133

29,23

4

Greater than 75%

61

9,5

102

22,42

Age at first delivery

0

Less than 20 years

33

5,14

23

5,05

2

1,4

2

1,46

1,15

1.02–1.31

0,03

1

From 20 to 24 years

165

25,7

104

22,86

2

From 25 to 29 years

203

31,62

107

23,52

3

From 30 to 34 years

106

16,51

101

22,2

4

Greater than 34 years

56

8,72

50

10,99

5

Nulliparous

79

12,31

70

15,38

Age at menopause

0

Less than 46 years

97

15,11

47

10,33

2

1,4

3

1,13

1,96

1.72–2.24

2,20E-16

1

From 46 to 50 years

147

22,9

102

22,42

2

Greater than 50 years

110

17,13

71

15,6

3

Premenopause

87

13,55

212

46,59

4

Menstruating

201

31,31

23

4,97

Age at menarche

0

Equal to or greater than 15 years

34

5,3

34

7,47

2

1,21

3

1,2

0,89

0.78–1.04

0,061

1

14 years

115

17,91

85

18,68

2

13 years

178

27,73

100

21,98

3

12 years

140

21,81

110

24,18

4

Less than 12 years

175

27,26

123

27,03

5

Null

0

0

3

0,66

Family antecedents

0

No affected relative

468

72,9

308

67,69

0

1,16

0

1,23

1,05

0.93–1.19

0,34

1

A first-degree relative diagnosed with breast cancer at age 50 years or older

52

8,1

43

9,45

2

A first-degree relative diagnosed with breast cancer when younger than 50 years

25

3,89

18

3,96

3

1 affected second-degree relative

90

14,02

79

17,36

4

2 affected first-degree relatives

4

0,62

5

1,1

5

2 affected second-degree relatives

1

0,16

2

0,44

6

3 or more affected relatives

2

0,31

0

0