Fig. 6

Changes in the expression of hypoxia-related proteins after three cycles of CKD-516 combined with IR. Qualitative (top) and quantitative (bottom) expression of hypoxia-related proteins, including HIF-1α, VEGF, and Glut-1 after IHC staining. Mice were divided into four groups according to the administration methods: vehicle (PBS), IR alone (2 Gy/day), CKD-516 alone (3 mg/kg), and CKD-516 (3 mg/kg, day 1) combined with IR (n = 10 per group). The data are presented as the mean ± SE. * denotes p < 0.05 and ** denotes p < 0.01. Scale bar: 100 μm. Magnification: × 20