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Table 1 Main characteristics of all studies included in the meta-analysis

From: Prognostic role of vitamin D receptor in breast cancer: a systematic review and meta-analysis

Study Country Case number High expression (%) Pathological type Molecular type Staining location Tumor stage Follow-up (months) Cut-off value Multivariate analysis HRs provided from Outcome NOS score
Heublein 2017 [16] Germany 117 57 (48.7) NR Multiple Nucleus Multiple Mean 81.8 IRS > 4.14 No SC OS 6
Huss 2019 [17] Sweden 678 553 (81.6) Multiple Multiple Nucleus Multiple NR Positive cells > 10% No Report CSS 8
Al-Azhri 2017 [18] America 1114 283 (25.5) NR Multiple Nucleus Multiple Median 72 (3–201) IRS > 5 Yes Report OS/PFS/CSS 8
Ditsch 2012 [19] Germany 82 75 (91.5) Invasive ductal Multiple Nucleus and cytoplasm NR NR IRS > 5 Yes Report OS/DFS 7
Soljic 2017 [20] Yugoslavia 96 26 (27) Multiple Triple negative Nucleus and cytoplasm I-IIIa Mean 69 (3–143) NR No Report OS/DFS 7
Ishida 2018 [21] Japan 144 NR NR NR Nucleus I-III Mean 7.7 (6–129) NR No Report DFS 8
Zehni (unifocal) 2019 [22] Germany 155 66 (42.6) Multiple Multiple Nucleus NR NR IRS > 25 Yes Report OS/DFS 7
Zehni (multifocal) 2019 [22] Germany 117 60 (51.3) Multiple Multiple Nucleus NR NR IRS > 25 Yes Report OS/DFS 7
  1. NR Not report, IRS Immunoreactive score, HR Hazard ratio, SC Survival curve, OS Overall survival, CSS Cancer-specific survival, PFS Progression-free survival, DFS Disease-free survival, NOS Newcastle-Ottawa Quality Assessment Scale