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Table 4 Association between clinicopathologic characteristics and HCC patient DFI through univariate and multivariate analysis with Cox regression survival model

From: Increased E2F2 predicts poor prognosis in patients with HCC based on TCGA data

Characteristics Univariate analysis Multivariate analysis
HR 95%CI P-value HR 95%CI P-value
CDK6 (high vs. low) 0.7 0.4–1.1 0.147 0.7 0.4–1.3 0.310
RB1 expression (high vs. low) 0.7 0.4–1.2 0.213 1.1 0.6–2.1 0.656
Age (>40 vs. ≤ 40) 0.6 0.3–1.2 0.167 0.9 0.4–1.9 0.748
Gender (male vs. female) 1.0 0.6–1.6 0.862    
Alcohol consumption (yes vs. no) 1.0 0.6–1.9 0.915    
Histologic grade (G3–4 vs. G1–2) 1.4 1.0–1.9 0.083 1.3 0.9–1.8 0.228
M (M1 vs. M0) 5.5 0.7–40.4 0.722    
N (N1 vs. N0) 3.9 0.5–28.6 0.180 1.1 0.0–119.9 0.953
T (T3–4 vs. T1–2) 1.6 1.2–2.1 0.001 0.8 0.1–5.9 0.800
Clinical stage (III-IV vs. I-II) 1.7 1.3–2.3 0.000 2.5 0.3–21.2 0.389
Postoperative ablation embolization (yes vs. no) 3.1 1.6–6.0 0.001 4.3 2.0–9.4 0.000
Radiation therapy (yes vs. no) 1.5 0.2–10.9 0.690    
Vascular invasion (yes vs. no) 1.2 0.7–2.1 0.524    
Family history of cancer (yes vs. no) 1.2 0.7–2.0 0.513    
E2F2 (high vs. low) 2.2 1.3–3.7 0.004 2.0 1.1–3.7 0.029
  1. DFI Disease-free interval, T = topography distribution, N = lymph node metastasis, M = distant metastasis, CI Confidence interval