Table 3 Association between clinicopathologic characteristics and HCC patient OS through univariate and multivariate analysis with Cox regression survival model

CDK6 (high vs. low)

0.8

0.4–1.4

0.400

1.0

0.5–2.0

0.973

RB1 expression (high vs. low)

0.7

0.4–1.3

0.230

0.7

0.3–1.4

0.298

Age (>40 vs. ≤ 40)

2.1

0.6–6.8

0.224

2.7

0.7–9.4

0.131

Gender (male vs. female)

0.6

0.3–1.1

0.082

1.0

0.5–2.0

0.951

Alcohol consumption (yes vs. no)

0.7

0.3–1.6

0.381

0.6

0.2–1.4

0.245

Histologic grade (G3–4 vs. G1–2)

1.3

0.8–1.9

0.293

1.3

0.8–1.9

0.312

M (M1 vs. M0)

4.8

0.7–35.5

0.122

2.4

0.4–13.9

0.323

N (N1 vs. N0)

3.8

0.5–28.0

0.188

0.1

0.0–17.4

0.352

T (T3–4 vs. T1–2)

1.4

1.0–2.0

0.033

0.2

0.0–1.9

0.160

Clinical stage (III-IV vs. I-II)

1.5

1.1–2.1

0.012

6.8

0.6–74.5

0.115

Postoperative ablation embolization (yes vs. no)

1.1

0.4–2.9

0.800

Radiation therapy (yes vs. no)

1.2

0.2–9.0

0.997

Family history of cancer (yes vs. no)

1.5

0.8–2.8

0.197

1.7

0.9–3.1

0.111

Vascular invasion (yes vs. no)

1.3

0.7–2.5

0.384

1.2

0.6–2.3

0.682

E2F2 (high vs. low)

2.0

1.3–3.2

0.002

2.4

1.3–4.2

0.004