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Table 3 Association between clinicopathologic characteristics and HCC patient OS through univariate and multivariate analysis with Cox regression survival model

From: Increased E2F2 predicts poor prognosis in patients with HCC based on TCGA data

Characteristics Univariate analysis Multivariate analysis
HR 95%CI P-value HR 95%CI P-value
CDK6 (high vs. low) 0.8 0.4–1.4 0.400 1.0 0.5–2.0 0.973
RB1 expression (high vs. low) 0.7 0.4–1.3 0.230 0.7 0.3–1.4 0.298
Age (>40 vs. ≤ 40) 2.1 0.6–6.8 0.224 2.7 0.7–9.4 0.131
Gender (male vs. female) 0.6 0.3–1.1 0.082 1.0 0.5–2.0 0.951
Alcohol consumption (yes vs. no) 0.7 0.3–1.6 0.381 0.6 0.2–1.4 0.245
Histologic grade (G3–4 vs. G1–2) 1.3 0.8–1.9 0.293 1.3 0.8–1.9 0.312
M (M1 vs. M0) 4.8 0.7–35.5 0.122 2.4 0.4–13.9 0.323
N (N1 vs. N0) 3.8 0.5–28.0 0.188 0.1 0.0–17.4 0.352
T (T3–4 vs. T1–2) 1.4 1.0–2.0 0.033 0.2 0.0–1.9 0.160
Clinical stage (III-IV vs. I-II) 1.5 1.1–2.1 0.012 6.8 0.6–74.5 0.115
Postoperative ablation embolization (yes vs. no) 1.1 0.4–2.9 0.800    
Radiation therapy (yes vs. no) 1.2 0.2–9.0 0.997    
Family history of cancer (yes vs. no) 1.5 0.8–2.8 0.197 1.7 0.9–3.1 0.111
Vascular invasion (yes vs. no) 1.3 0.7–2.5 0.384 1.2 0.6–2.3 0.682
E2F2 (high vs. low) 2.0 1.3–3.2 0.002 2.4 1.3–4.2 0.004
  1. OS Overall survival, T = topography distribution, N = lymph node metastasis; M = distant metastasis, CI Confidence interval